Document Detail


Arachidonate 12-lipoxygenases.
MedLine Citation:
PMID:  12432922     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arachidonate 12-lipoxygenase introduces a molecular oxygen at carbon 12 of arachidonic acid to generate a 12-hydroperoxy derivative. The enzymes generate 12-hydroperoxy derivatives with either S- or R-configurations. There are three isoforms of 12S-lipoxygenases named after the cells where they were first identified; platelet, leukocyte and epidermis. The leukocyte-type enzyme is widely distributed among cells, but the tissue distribution varies substantially from species to species. The platelet and epidermal enzymes are present in only a relatively limited number of cell types. Although the structures and enzymatic properties of the three isoforms of 12S-lipoxygenases have been elucidated, the physiological roles of the 12S-lipoxygenases are not yet fully understood. There are important roles for the enzymes and their products in several biological systems including those involved in atherosclerosis and neurotransmission.
Authors:
Tanihiro Yoshimoto; Yoshitaka Takahashi
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prostaglandins & other lipid mediators     Volume:  68-69     ISSN:  1098-8823     ISO Abbreviation:  Prostaglandins Other Lipid Mediat.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-11-15     Completed Date:  2003-07-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9808648     Medline TA:  Prostaglandins Other Lipid Mediat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-62     Citation Subset:  IM    
Affiliation:
Department of Molecular Pharmacology, Kanazawa University Graduate School of Medicine, Japan. yoshimot@med.kanazawa-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / metabolism
Animals
Arachidonate 12-Lipoxygenase / chemistry,  genetics,  metabolism*
Cytokines / metabolism
Gene Expression Regulation, Enzymologic
Growth Substances / metabolism
Humans
Isoenzymes / genetics,  metabolism
Nervous System / enzymology
RNA, Messenger / metabolism
Tissue Distribution
Chemical
Reg. No./Substance:
0/Cytokines; 0/Growth Substances; 0/Isoenzymes; 0/RNA, Messenger; 59985-28-3/12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; EC 1.13.11.31/Arachidonate 12-Lipoxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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