| Arachidonate 12-lipoxygenases. | |
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MedLine Citation:
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PMID: 12432922 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arachidonate 12-lipoxygenase introduces a molecular oxygen at carbon 12 of arachidonic acid to generate a 12-hydroperoxy derivative. The enzymes generate 12-hydroperoxy derivatives with either S- or R-configurations. There are three isoforms of 12S-lipoxygenases named after the cells where they were first identified; platelet, leukocyte and epidermis. The leukocyte-type enzyme is widely distributed among cells, but the tissue distribution varies substantially from species to species. The platelet and epidermal enzymes are present in only a relatively limited number of cell types. Although the structures and enzymatic properties of the three isoforms of 12S-lipoxygenases have been elucidated, the physiological roles of the 12S-lipoxygenases are not yet fully understood. There are important roles for the enzymes and their products in several biological systems including those involved in atherosclerosis and neurotransmission. |
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Authors:
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Tanihiro Yoshimoto; Yoshitaka Takahashi |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Prostaglandins & other lipid mediators Volume: 68-69 ISSN: 1098-8823 ISO Abbreviation: Prostaglandins Other Lipid Mediat. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-11-15 Completed Date: 2003-07-10 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9808648 Medline TA: Prostaglandins Other Lipid Mediat Country: United States |
Other Details:
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Languages: eng Pagination: 245-62 Citation Subset: IM |
Affiliation:
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Department of Molecular Pharmacology, Kanazawa University Graduate School of Medicine, Japan. yoshimot@med.kanazawa-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
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metabolism Animals Arachidonate 12-Lipoxygenase / chemistry, genetics, metabolism* Cytokines / metabolism Gene Expression Regulation, Enzymologic Growth Substances / metabolism Humans Isoenzymes / genetics, metabolism Nervous System / enzymology RNA, Messenger / metabolism Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Growth Substances; 0/Isoenzymes; 0/RNA, Messenger; 59985-28-3/12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; EC 1.13.11.31/Arachidonate 12-Lipoxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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