| Arabidopsis FAB1A/B is possibly involved in the recycling of auxin transporters. | |
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MedLine Citation:
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PMID: 21412048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fab1/PIKfyve produces Phosphatidylinositol 3,5-bisphosphate (PtdIns (3,5) P2) from Phosphatidylinositol 3-phosphate (PtdIns 3-P), and is involved not only in vacuole/lysosome homeostasis, but also in transporting various proteins to the vacuole or recycling proteins on the plasma membrane (PM) through the use of endosomes in a variety of eukaryotic cells. We previously demonstrated that Arabidopsis FAB1A/B functions as PtdIns 3,5-kinase in both Arabidopsis and fission yeast and plays a key role in vacuolar acidification and endocytosis. Although the conditional FAB1A/B knockdown mutant revealed an auxin-resistant phenotype to a membrane impermeable auxin, 2,4-dichlorophenoxyacetic acid (2,4-D), the mutant did not exhibit this phenotype to a membrane-permeable artificial auxin, naphthalene 1-acetic acid (NAA). The difference in the sensitivities to 2,4-D and NAA is similar to those of the auxin-resistant mutants such as aux1. Taken together, these results suggest that impairment of the function of Arabidopsis FAB1A/B might cause a defect in the membrane recycling capabilities of the auxin transporters and inhibit proper auxin transport into the cells in Arabidopsis. |
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Authors:
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Tomoko Hirano; Masa H Sato |
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Publication Detail:
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Type: Journal Article Date: 2011-04-01 |
Journal Detail:
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Title: Plant signaling & behavior Volume: 6 ISSN: 1559-2324 ISO Abbreviation: Plant Signal Behav Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-06-15 Completed Date: 2011-10-04 Revised Date: 2012-04-27 |
Medline Journal Info:
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Nlm Unique ID: 101291431 Medline TA: Plant Signal Behav Country: United States |
Other Details:
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Languages: eng Pagination: 583-5 Citation Subset: IM |
Affiliation:
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Graduate School of Biostudies, Kyoto University, Kyoto, Japan. mhsato@kpu.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2,4-Dichlorophenoxyacetic Acid
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pharmacology Arabidopsis / drug effects, genetics, metabolism* Arabidopsis Proteins / genetics, metabolism* Biological Transport Indoleacetic Acids / pharmacology Membrane Transport Proteins / genetics, metabolism* Naphthaleneacetic Acids / pharmacology Phosphotransferases (Alcohol Group Acceptor) / genetics, metabolism* Plants, Genetically Modified / drug effects, genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Arabidopsis Proteins; 0/Indoleacetic Acids; 0/Membrane Transport Proteins; 0/Naphthaleneacetic Acids; 94-75-7/2,4-Dichlorophenoxyacetic Acid; EC 2.7.1.-/FAB1A protein, Arabidopsis; EC 2.7.1.-/FAB1B protein, Arabidopsis; EC 2.7.1.-/Phosphotransferases (Alcohol Group Acceptor) |
| Comments/Corrections | |
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