| Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid. | |
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MedLine Citation:
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PMID: 20498067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Differential distribution of the plant hormone auxin within tissues mediates a variety of developmental processes. Cellular auxin levels are determined by metabolic processes including synthesis, degradation, and (de)conjugation, as well as by auxin transport across the plasma membrane. Whereas transport of free auxins such as naturally occurring indole-3-acetic acid (IAA) is well characterized, little is known about the transport of auxin precursors and metabolites. Here, we identify a mutation in the ABCG37 gene of Arabidopsis that causes the polar auxin transport inhibitor sensitive1 (pis1) phenotype manifested by hypersensitivity to auxinic compounds. ABCG37 encodes the pleiotropic drug resistance transporter that transports a range of synthetic auxinic compounds as well as the endogenous auxin precursor indole-3-butyric acid (IBA), but not free IAA. ABCG37 and its homolog ABCG36 act redundantly at outermost root plasma membranes and, unlike established IAA transporters from the PIN and ABCB families, transport IBA out of the cells. Our findings explore possible novel modes of regulating auxin homeostasis and plant development by means of directional transport of the auxin precursor IBA and presumably also other auxin metabolites. |
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Authors:
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Kamil Ruzicka; Lucia C Strader; Aurélien Bailly; Haibing Yang; Joshua Blakeslee; Lukasz Langowski; Eliska Nejedlá; Hironori Fujita; Hironori Itoh; Kunihiko Syono; Jan Hejátko; William M Gray; Enrico Martinoia; Markus Geisler; Bonnie Bartel; Angus S Murphy; Jirí Friml |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-05-24 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-07-19 Revised Date: 2011-03-03 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 10749-53 Citation Subset: IM |
Affiliation:
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Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, 9052 Ghent, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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genetics,
metabolism* Arabidopsis / genetics, growth & development, metabolism* Arabidopsis Proteins / genetics, metabolism* Base Sequence Homeostasis Indoleacetic Acids / metabolism* Indoles / metabolism* Mutation Plant Roots / genetics, growth & development, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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1K99GM089987/GM/NIGMS NIH HHS; GM067203/GM/NIGMS NIH HHS; R01 GM067203-04/GM/NIGMS NIH HHS; R01 GM067203-05/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/ATP-Binding Cassette Transporters; 0/Arabidopsis Proteins; 0/Indoleacetic Acids; 0/Indoles; 0/PDR9 protein, Arabidopsis; 133-32-4/indolebutyric acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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