Document Detail


Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid.
MedLine Citation:
PMID:  20498067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Differential distribution of the plant hormone auxin within tissues mediates a variety of developmental processes. Cellular auxin levels are determined by metabolic processes including synthesis, degradation, and (de)conjugation, as well as by auxin transport across the plasma membrane. Whereas transport of free auxins such as naturally occurring indole-3-acetic acid (IAA) is well characterized, little is known about the transport of auxin precursors and metabolites. Here, we identify a mutation in the ABCG37 gene of Arabidopsis that causes the polar auxin transport inhibitor sensitive1 (pis1) phenotype manifested by hypersensitivity to auxinic compounds. ABCG37 encodes the pleiotropic drug resistance transporter that transports a range of synthetic auxinic compounds as well as the endogenous auxin precursor indole-3-butyric acid (IBA), but not free IAA. ABCG37 and its homolog ABCG36 act redundantly at outermost root plasma membranes and, unlike established IAA transporters from the PIN and ABCB families, transport IBA out of the cells. Our findings explore possible novel modes of regulating auxin homeostasis and plant development by means of directional transport of the auxin precursor IBA and presumably also other auxin metabolites.
Authors:
Kamil Ruzicka; Lucia C Strader; Aurélien Bailly; Haibing Yang; Joshua Blakeslee; Lukasz Langowski; Eliska Nejedlá; Hironori Fujita; Hironori Itoh; Kunihiko Syono; Jan Hejátko; William M Gray; Enrico Martinoia; Markus Geisler; Bonnie Bartel; Angus S Murphy; Jirí Friml
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-05-24
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  107     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-07-19     Revised Date:  2013-10-21    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10749-53     Citation Subset:  IM    
Affiliation:
Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, 9052 Ghent, Belgium.
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MeSH Terms
Descriptor/Qualifier:
ATP-Binding Cassette Transporters / genetics,  metabolism*
Arabidopsis / genetics,  growth & development,  metabolism*
Arabidopsis Proteins / genetics,  metabolism*
Base Sequence
Homeostasis
Indoleacetic Acids / metabolism*
Indoles / metabolism*
Mutation
Plant Roots / genetics,  growth & development,  metabolism
Grant Support
ID/Acronym/Agency:
1K99GM089987/GM/NIGMS NIH HHS; GM067203/GM/NIGMS NIH HHS; R00 GM089987/GM/NIGMS NIH HHS; R01 GM067203/GM/NIGMS NIH HHS; R01 GM067203-04/GM/NIGMS NIH HHS; R01 GM067203-05/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Indoleacetic Acids; 0/Indoles; 0/PDR9 protein, Arabidopsis; 061SKE27JP/indolebutyric acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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