Document Detail


Aqueous lithium heparin is a superior anticoagulant to solid heparin for blood collection from the retro-orbital sinus of rats.
MedLine Citation:
PMID:  1921328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood specimens from the retro-orbital sinus of 80 Sprague Dawley rats were collected into tubes containing lithium heparin either as a solid or an aqueous solution. Plasma was separated for blood chemistry analysis. Twenty-eight blood specimens collected into tubes containing solid heparin were clotted and eight specimens were partially clotted making these samples unsuitable for some analyses. None of the specimens collected into heparin solution showed any evidence of clotting. The variances of lactate dehydrogenase and alpha-hydroxybutyrate dehydrogenase activities in plasma prepared with solid heparin were significantly greater than those prepared with heparin solution. Lithium heparin solution is now used routinely in our laboratory.
Authors:
M R Slaughter; J S Moen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animals     Volume:  25     ISSN:  0023-6772     ISO Abbreviation:  Lab. Anim.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-11-12     Completed Date:  1991-11-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0112725     Medline TA:  Lab Anim     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  272-6     Citation Subset:  IM    
Affiliation:
SmithKline Beecham Pharmaceuticals, Welwyn, Herts, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticoagulants*
Blood Specimen Collection* / methods
Heparin*
Hydroxybutyrate Dehydrogenase / blood
L-Lactate Dehydrogenase / blood
Lithium*
Male
Orbit*
Rats
Rats, Inbred Strains
Solutions
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Solutions; 7439-93-2/Lithium; 9005-49-6/Heparin; EC 1.1.1.-/2-hydroxybutyrate dehydrogenase; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.1.1.30/Hydroxybutyrate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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