Document Detail


Aqueous humour penetration of moxifloxocin and gatifloxacin eye drops in different dosing regimens before phacoemulsification surgery.
MedLine Citation:
PMID:  21030410     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To compare the aqueous humour penetration of moxifloxacin 0.5% and gatifloxacin 0.3% eye drops administered in two different dosing regimens during phacoemulsification surgery.
METHODS: This prospective, randomised study included 97 patients. The patients were randomly divided into two treatment groups to receive either moxifloxacin or gatifloxacin. All patients received the topical antibiotics four times per day for 2 days prior to surgery. Patients in each group were further subdivided to receive additional doses of antibiotic drops as two drops 30 min apart (subgroup 1) versus four drops 10 min apart (subgroup 2) 1 h prior to the surgery. At the beginning of surgery, 0.1 ml of aqueous humour was aspirated, and the concentrations of moxifloxacin and gatifloxacin were analysed by high-performance liquid chromatography.
RESULTS: The mean concentrations of moxifloxacin and gatifloxacin in the aqueous humour were 0.72 ± 0.40 μg/ml and 0.47 ± 0.29 μg/ml, respectively, in the first subgroup, and 1.95 ± 1.05 μg/ml and 0.77 ± 0.52 μg/ml, respectively, in the second subgroup. Both the inter-group (p=0.006 and p=0.000, respectively) and the intra-group (p=0.000 and p=0.035, respectively) differences between the aqueous humour concentrations of moxifloxacin and gatifloxacin subgroups were statistically significant.
CONCLUSION: Moxifloxacin, given in the same dosage, penetrated the aqueous humour better then gatifloxacin during cataract surgery. The penetration of both antibiotics increased significantly when the dosage of the agent was doubled.
Authors:
Sirel Gür Güngör; Yonca Aydin Akova; Atila Bozkurt; Ümit Yasar; Melih Ö Babaoğlu; Altuğ Çetinkaya; Meriç Çolak
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-10-28
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  95     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-22     Completed Date:  2011-11-02     Revised Date:  2013-04-24    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1272-5     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Basxkent University, Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Aged
Anti-Infective Agents / administration & dosage,  pharmacokinetics
Aqueous Humor / metabolism*
Aza Compounds / administration & dosage,  pharmacokinetics*
Cataract / metabolism*
Chromatography, High Pressure Liquid
Dose-Response Relationship, Drug
Endophthalmitis / prevention & control*
Female
Fluoroquinolones / administration & dosage,  pharmacokinetics*
Humans
Male
Ophthalmic Solutions
Phacoemulsification*
Preoperative Care
Prospective Studies
Quinolines / administration & dosage,  pharmacokinetics*
Surgical Wound Infection / prevention & control*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Aza Compounds; 0/Fluoroquinolones; 0/Ophthalmic Solutions; 0/Quinolines; L4618BD7KJ/gatifloxacin; U188XYD42P/moxifloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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