Document Detail


Aqueous concentration of tranexamic acid after 5% and 10% eyedrop administration.
MedLine Citation:
PMID:  19551684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To determine whether topical tranexamic acid can provide acceptable therapeutic concentration in the aqueous humor. METHODS: A total of 47 patients with cataract as the sole eye disease who have been scheduled for cataract operation received one drop of tranexamic acid 5% solution at various time intervals prior to operation (from 15 minutes to 9 hours). Two patients received 10% solution of the drug. Paracentesis of the anterior chamber was done and the aqueous humor was aspirated in the operation room. The aqueous samples were analyzed using high-performance liquid chromatography method with the limit of quantification around 0.1 microg/mL. Systemic and ocular side effects were evaluated. RESULTS: Aqueous concentrations of tranexamic acid was higher than 1.5 microg/mL up to 160 minutes after administration of a single drop of 5% solution of the drug and then declined to an average concentration of 1 microg/mL at 300 minutes which persisted up to 9 hours after administration.In two patients for whom a single drop of 10% tranexamic acid solution was used, aqueous concentrations of 2.72 and 2.90 microg/mL were detected 60 minutes after administration. None of the patients experienced ocular or systemic side effects. CONCLUSIONS: Topical administration of tranexamic acid is effective in yielding therapeutic intraocular concentrations of drug without any ocular or systemic toxicity.
Authors:
Hamid R Jahadi Hosseini; Hashem Montaseri; Mohammad R Khalili; Shohreh A Simakani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of ophthalmology     Volume:  19     ISSN:  1120-6721     ISO Abbreviation:  Eur J Ophthalmol     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-06-24     Completed Date:  2009-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110772     Medline TA:  Eur J Ophthalmol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  661-6     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Khalili Hospital, Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz - Iran. hamidjahadi@yahoo.com.uk
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adult
Aged
Aged, 80 and over
Antifibrinolytic Agents / administration & dosage,  pharmacokinetics*
Aqueous Humor / metabolism*
Biological Availability
Cataract / metabolism
Chromatography, High Pressure Liquid
Female
Humans
Hyphema / drug therapy
Male
Middle Aged
Tranexamic Acid / administration & dosage,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Antifibrinolytic Agents; 1197-18-8/Tranexamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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