| Aqueous concentration of tranexamic acid after 5% and 10% eyedrop administration. | |
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MedLine Citation:
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PMID: 19551684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine whether topical tranexamic acid can provide acceptable therapeutic concentration in the aqueous humor. METHODS: A total of 47 patients with cataract as the sole eye disease who have been scheduled for cataract operation received one drop of tranexamic acid 5% solution at various time intervals prior to operation (from 15 minutes to 9 hours). Two patients received 10% solution of the drug. Paracentesis of the anterior chamber was done and the aqueous humor was aspirated in the operation room. The aqueous samples were analyzed using high-performance liquid chromatography method with the limit of quantification around 0.1 microg/mL. Systemic and ocular side effects were evaluated. RESULTS: Aqueous concentrations of tranexamic acid was higher than 1.5 microg/mL up to 160 minutes after administration of a single drop of 5% solution of the drug and then declined to an average concentration of 1 microg/mL at 300 minutes which persisted up to 9 hours after administration.In two patients for whom a single drop of 10% tranexamic acid solution was used, aqueous concentrations of 2.72 and 2.90 microg/mL were detected 60 minutes after administration. None of the patients experienced ocular or systemic side effects. CONCLUSIONS: Topical administration of tranexamic acid is effective in yielding therapeutic intraocular concentrations of drug without any ocular or systemic toxicity. |
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Authors:
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Hamid R Jahadi Hosseini; Hashem Montaseri; Mohammad R Khalili; Shohreh A Simakani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of ophthalmology Volume: 19 ISSN: 1120-6721 ISO Abbreviation: Eur J Ophthalmol Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-06-24 Completed Date: 2009-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110772 Medline TA: Eur J Ophthalmol Country: Italy |
Other Details:
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Languages: eng Pagination: 661-6 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Khalili Hospital, Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz - Iran. hamidjahadi@yahoo.com.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Aged Aged, 80 and over Antifibrinolytic Agents / administration & dosage, pharmacokinetics* Aqueous Humor / metabolism* Biological Availability Cataract / metabolism Chromatography, High Pressure Liquid Female Humans Hyphema / drug therapy Male Middle Aged Tranexamic Acid / administration & dosage, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Antifibrinolytic Agents; 1197-18-8/Tranexamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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