| Aqueous Extracts of Fructus Ligustri Lucidi Enhance the Sensitivity of Human Colorectal Carcinoma DLD-1 Cells to Doxorubicin-Induced Apoptosis via Tbx3 Suppression. | |
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MedLine Citation:
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PMID: 20702496 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Chemoresistance has imposed a great challenge for cancer therapy. Fructus Ligustri Lucidi (FLL) is one of the commonest Chinese herbs that has been used for thousand years. This study shows that the aqueous extract of FLL (AFLL) enhanced the sensitivity of DLD-1 colon cancer cells to doxorubicin-induced apoptosis. Furthermore, Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activated. Therefore, reduction of Tbx3 rescued the dysregulated P14(ARF)-P53 signaling, which in turn contributed to the sensitivity of DLD-1 cells to doxorubicin-induced apoptosis. As a conclusion, the findings suggest that FLL has a potential of being an appealing agent for auxiliary chemotherapy in treatment of human colorectal carcinoma. |
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Authors:
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Jin-Fang Zhang; Ming-Liang He; Qi Dong; Wei-Dong Xie; Yang-Chao Chen; Marie C M Lin; Ping-Chung Leung; Ya-Ou Zhang; Hsiang-Fu Kung |
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Publication Detail:
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Type: Journal Article Date: 2010-08-11 |
Journal Detail:
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Title: Integrative cancer therapies Volume: 10 ISSN: 1552-695X ISO Abbreviation: Integr Cancer Ther Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128834 Medline TA: Integr Cancer Ther Country: United States |
Other Details:
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Languages: eng Pagination: 85-91 Citation Subset: IM |
Affiliation:
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Tsinghua University, Beijing, People's Republic of China, Tsinghua University, Shenzhen, People's Republic of China, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. |
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