Document Detail

Aqueductal stenosis and hydrocephalus in an infant due to aspergillus infection.
MedLine Citation:
PMID:  10774948     Owner:  NLM     Status:  MEDLINE    
Aqueductal stenosis is a common cause of hydrocephalus during infancy. We report on an infant born with aplasia cutis congenita at the scalp vertex and hypoplastic left heart syndrome developing systemic aspergillosis after cardiac surgery. The infant died at the age of 76 days despite systemic antimycotic therapy with a combination of flucytosine and amphotericin B. Therapy started at post-operative day 17 and was also applied intrathecally. Post-mortem examination revealed meningitis, multiple brain aspergillomas and microabscesses with focal ependymitis, focal bronchopneumonia, and necrotizing enterocolitis. One of the brain aspergillomas was located close to the aqueduct causing an aqueductal stenosis and an obstructive hydrocephalus. Histologically, aspergillus hyphae could only be detected in the aspergilloma of the aqueduct. To the best of our knowledge, this is the first reported case of an aqueductal stenosis caused by an aspergilloma.
F K van Landeghem; B Stiller; T N Lehmann; N Sarioglu; B Sander; P E Lange; G Stoltenburg-Didinger
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical neuropathology     Volume:  19     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:    2000 Jan-Feb
Date Detail:
Created Date:  2000-07-11     Completed Date:  2000-07-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  26-9     Citation Subset:  IM    
Institute of Neuropathology, Humboldt-Universität, Berlin, Germany.
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MeSH Terms
Brain Stem / pathology
Cerebral Aqueduct / pathology*
Constriction, Pathologic / pathology
Ectodermal Dysplasia / pathology
Hydrocephalus / pathology*
Hypoplastic Left Heart Syndrome / pathology
Infant, Newborn
Meninges / pathology
Meningitis, Fungal / pathology*
Neuroaspergillosis / pathology*
Opportunistic Infections / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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