Document Detail

Aquatic hypoxia is a teratogen and affects fish embryonic development.
MedLine Citation:
PMID:  15487785     Owner:  NLM     Status:  MEDLINE    
Hypoxia occurs over large areas in aquatic systems worldwide, and there is growing concern that hypoxia may affect aquatic animals, leading to population decline and changes in community by elimination of sensitive species. For the first time, we report that sublethal levels of hypoxia can significantly increase (+77.4%) malformation in fish embryonic development. Disruption of apoptotic pattern was clearly evident at 24 h post-fertilization, which may be a major cause of malformation. Furthermore, embryonic development was delayed, and balance of sex hormones (testosterone and estradiol) was disturbed during embryonic stages, implicating that subsequent sexual development may also be affected. Overall, our results imply that hypoxia may have a teratogenic effect on fish and delay fish embryonic development, which may subsequently impair species fitness leading to natural population decline.
Eva H H Shang; Rudolf S S Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental science & technology     Volume:  38     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-18     Completed Date:  2005-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4763-7     Citation Subset:  IM    
Centre for Coastal Pollution and Conservation and Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, People's Republic of China.
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MeSH Terms
Cell Hypoxia
Embryo, Nonmammalian / abnormalities*,  physiology
Embryonic Development*
Estradiol / analysis
Heart Rate
Oxygen* / metabolism
Spine / abnormalities
Testosterone / analysis
Zebrafish / abnormalities*
Reg. No./Substance:
0/Teratogens; 50-28-2/Estradiol; 58-22-0/Testosterone; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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