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Aquatic exercise improves the monocyte pro- and anti-inflammatory cytokine production balance in fibromyalgia patients.
MedLine Citation:
PMID:  20536907     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Current hypotheses of the etiology of fibromyalgia (FM) include inflammatory disorders. We evaluated the effect of a pool-aquatic exercise program (8 months, two weekly 60-min sessions) on the inflammatory cytokine production by isolated monocytes, and on the serum concentration of C-reactive protein (CRP), in a group of female FM patients. Monocytes from FM patients released more IL-1β, TNFα, IL-6, and IL-10 than those from an age-matched control group of healthy women (HW). This inflammatory disorder in FM women was also manifested by high circulating concentrations of CRP. Increased IL-6 with a concomitant decreased TNFα spontaneous release was found after 4 months (midway through) of the exercise program. At the end of the program (8 months), monocytes from FM patients showed diminished spontaneous production of pro-/anti-inflammatory cytokines, with a similar spontaneous release of IL-1β and IL-6 to that of HW, but a lower production of TNFα and higher of IL-10. Lipopolysaccharide-induced production of IL-1β, TNFα, IL-6, and IL-10 also decreased at the end of the exercise program, although IL-10 remained higher than HW. The anti-inflammatory effect of the exercise program was also corroborated by a decrease in the circulating CRP concentration. Exercise also improved the health-related quality of life of FM patients.
Authors:
E Ortega; M E Bote; E Giraldo; J J García
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Publication Detail:
Type:  Journal Article     Date:  2010-06-01
Journal Detail:
Title:  Scandinavian journal of medicine & science in sports     Volume:  22     ISSN:  1600-0838     ISO Abbreviation:  Scand J Med Sci Sports     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111504     Medline TA:  Scand J Med Sci Sports     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  104-12     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Affiliation:
Research Group in Immunophysiology: Exercise, Stress and Health, Department of Physiology, Faculty of Sciences, University of Extremadura, Badajoz, Spain.
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