Document Detail


Aquaporins in cerebrovascular disease: a target for treatment of brain edema?
MedLine Citation:
PMID:  21487216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In cerebrovascular disease, edema formation is frequently observed within the first 7 days and is characterized by molecular and cellular changes in the neurovascular unit. The presence of water channels, aquaporins (AQPs), within the neurovascular unit has led to intensive research in understanding the underlying roles of each of the AQPs under normal conditions and in different diseases. In this review, we summarize some of the recent knowledge on AQPs, focusing on AQP4, the most abundant AQP in the central nervous system. Several experimental models illustrate that AQPs have dual, complex regulatory roles in edema formation and resolution. To date, no specific therapeutic agents have been developed to inhibit water flux through these channels. However, experimental results strongly suggest that this is an important area for future investigation. In fact, early inhibition of water channels may have positive effects in the prevention of edema formation. At later time points during the course of disease, AQP is important for the clearance of water from the brain into blood vessels. Thus, AQPs, and in particular AQP4, have important roles in the resolution of edema after brain injury. The function of these water channel proteins makes them an excellent therapeutic target.
Authors:
J Badaut; S Ashwal; A Obenaus
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-04-12
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  31     ISSN:  1421-9786     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-10     Completed Date:  2011-09-01     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  521-31     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Department of Pediatrics, Loma Linda University School of Medicine, Calif., USA. jbadaut@llu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Aquaporins / physiology*
Basal Ganglia Cerebrovascular Disease / physiopathology*,  therapy*
Brain Edema / physiopathology*,  therapy*
Humans
Water / metabolism
Grant Support
ID/Acronym/Agency:
R01HD061946/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Aquaporins; 7732-18-5/Water
Comments/Corrections

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