Document Detail


Aquaporin-4 gene variation and sudden infant death syndrome.
MedLine Citation:
PMID:  20351659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to investigate the aquaporin-4 (AQP4) gene in cases of sudden infant death syndrome (SIDS) and controls and to elucidate the hypothesis that a genetically determined disturbed water homeostasis in the brain is involved as a predisposing factor in SIDS. The single nucleotide polymorphisms (SNPs) rs2075575, rs4800773, rs162004, and rs3763043 in the AQP4 gene were investigated in 141 SIDS cases and 179 controls. For each SIDS case, a brain/body weight ratio was calculated. The study revealed an association between the T allele and the CT/TT genotypes of rs2075575 and SIDS (C versus T, p < 0.01; CC versus CT/TT, p = 0.03). For the other three investigated SNPs, there were no differences in genotype frequencies between SIDS cases and controls. For the SNP rs2075575, it was also found an association between brain/body weight ratio and genotype in the SIDS cases aged 0.3-12 wk (p = 0.014, median ratio CC 10.6, CT/TT 12.1). In conclusion, this study indicates that rs2075575 may be of significance as a predisposing factor for SIDS, and that the CT/TT genotypes are associated with an increased brain/body weight ratio in infants dying from SIDS during the vulnerable period from birth up to 3 mo of age.
Authors:
Siri H Opdal; Ashild Vege; Arne Stray-Pedersen; Torleiv O Rognum
Related Documents :
8440089 - The isolation of cytotoxic necrotizing factor (cnf)-producing escherichia coli from the...
11236409 - Sudden infant death syndrome, maternal smoking during pregnancy, and the cost-effective...
7669379 - Has changing diagnostic preference been responsible for the recent fall in incidence of...
11453089 - Chlamydia and sudden infant death syndrome. a study of 166 sids and 30 control cases.
8148189 - Carbon dioxide concentrations in the environment of sleeping infants.
1895969 - Early parental responses to sudden infant death, stillbirth or neonatal death.
20377589 - Gene expression profiles of infant acute lymphoblastic leukaemia and its prognostically...
17033529 - Effects of age and time on energy and macronutrient intake in german infants and young ...
9494299 - Prenatal infant feeding intent and perceived social support for breastfeeding in manito...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  68     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-16     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  48-51     Citation Subset:  IM    
Affiliation:
Institute of Forensic Medicine, University of Oslo, Oslo 0027, Norway. s.h.opdal@medisin.uio.no
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alleles
Animals
Aquaporin 4 / genetics*
Female
Genetic Predisposition to Disease*
Genotype
Homeostasis
Humans
Infant
Male
Mice
Polymorphism, Single Nucleotide*
Risk Factors
Sequence Analysis, DNA
Sudden Infant Death / genetics*
Water / metabolism*
Chemical
Reg. No./Substance:
0/Aquaporin 4; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Metabolomics Of Volatile Organic Compounds In Cystic Fibrosis Patients and Controls.
Next Document:  Embryological background of truncular venous malformation in the extracranial venous pathways as the...