| Aquaporin-4 deficiency impairs synaptic plasticity and associative fear memory in the lateral amygdala: involvement of downregulation of glutamate transporter-1 expression. | |
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MedLine Citation:
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PMID: 22473056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Astrocytes are implicated in information processing, signal transmission, and regulation of synaptic plasticity. Aquaporin-4 (AQP4) is the major water channel in adult brain and is primarily expressed in astrocytes. A growing body of evidence indicates that AQP4 is a potential molecular target for the regulation of astrocytic function. However, little is known about the role of AQP4 in synaptic plasticity in the amygdala. Therefore, we evaluated long-term potentiation (LTP) in the lateral amygdala (LA) and associative fear memory of AQP4 knockout (KO) and wild-type mice. We found that AQP4 deficiency impaired LTP in the thalamo-LA pathway and associative fear memory. Furthermore, AQP4 deficiency significantly downregulated glutamate transporter-1 (GLT-1) expression and selectively increased NMDA receptor (NMDAR)-mediated EPSCs in the LA. However, low concentration of NMDAR antagonist reversed the impairment of LTP in KO mice. Upregulating GLT-1 expression by chronic treatment with ceftriaxone also reversed the impairment of LTP and fear memory in KO mice. These findings imply a role for AQP4 in synaptic plasticity and associative fear memory in the amygdala by regulating GLT-1 expression. |
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Authors:
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Yan-Kun Li; Fang Wang; Wei Wang; Yi Luo; Peng-Fei Wu; Jun-Li Xiao; Zhuang-Li Hu; You Jin; Gang Hu; Jian-Guo Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-04-04 |
Journal Detail:
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Title: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Volume: 37 ISSN: 1740-634X ISO Abbreviation: Neuropsychopharmacology Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-18 Completed Date: 2012-11-13 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8904907 Medline TA: Neuropsychopharmacology Country: England |
Other Details:
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Languages: eng Pagination: 1867-78 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Hubei, Wuhan, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amygdala
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metabolism*,
physiology* Animals Aquaporin 4 / genetics* Ceftriaxone / pharmacology Down-Regulation / physiology Excitatory Amino Acid Transporter 2 / biosynthesis* Excitatory Postsynaptic Potentials / physiology Fear / psychology* Long-Term Potentiation / physiology Male Memory / physiology* Mice Mice, Knockout Neural Pathways / physiology Neuronal Plasticity / physiology* Receptors, N-Methyl-D-Aspartate / physiology Thalamus / physiology Up-Regulation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Aquaporin 4; 0/Excitatory Amino Acid Transporter 2; 0/Receptors, N-Methyl-D-Aspartate; 73384-59-5/Ceftriaxone |
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