| Aquaporin 3 cloned from Xenopus laevis is regulated by the cystic fibrosis transmembrane conductance regulator. | |
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MedLine Citation:
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PMID: 10869574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cystic fibrosis transmembrane conductance regulator (CFTR) is essential for epithelial electrolyte transport and has been shown to be a regulator of epithelial Na(+), K(+), and Cl(-) channels. CFTR also enhances osmotic water permeability when activated by cAMP. This was detected initially in Xenopus oocytes and is also present in human airway epithelial cells, however, the mechanisms remain obscure. Here, we show that CFTR activates aquaporin 3 expressed endogenously and exogenously in oocytes of Xenopus laevis. The interaction requires stimulation of wild type CFTR by cAMP and an intact first nucleotide binding domain as demonstrated for other CFTR-protein interactions. |
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Authors:
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R Schreiber; H Pavenstädt; R Greger; K Kunzelmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 475 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-07-24 Completed Date: 2000-07-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 291-5 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, University of Queensland, St. Lucia, Brisbane, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Aquaporin 3 Aquaporins / genetics*, metabolism* Cloning, Molecular Cyclic AMP / metabolism Cystic Fibrosis Transmembrane Conductance Regulator / metabolism* Female Humans Molecular Sequence Data Oocytes Xenopus laevis |
| Chemical | |
Reg. No./Substance:
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0/Aquaporins; 0/CFTR protein, human; 126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator; 158801-98-0/Aquaporin 3; 60-92-4/Cyclic AMP |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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