Document Detail


Aquaporin-2 urinary excretion in cirrhosis: relationship to vasopressin and nitric oxide.
MedLine Citation:
PMID:  19495975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aquaporin (AQP) water channel plays an important role in the regulation of water. AQP2 is expressed in the collection duct of the kidney, serving as the final channel that helps to regulate water excretion in the kidneys and affecting the regulation of water and hyponatremia in cirrhotic patients. So far, research on aquaporin expression in cirrhosis has had various results. The purpose of this study is to investigate the factors that affect the regulation of expression of AQP in patients with cirrhosis. The study comprised 81 cirrhosis patients and 18 control subjects. In each group, 24-h urine was collected and nitric oxide and vasopressin levels were measured in the blood. The amount of urinary AQP was measured by Western blot. In this study, the positivity rate and amount of expression of AQP was higher in the cirrhotic group than that of the control group. AQP expression in urine was also compared between the groups with use of diuretics and the groups with no use of diuretics. A 57.4% positivity was observed with the former, whereas a 51.5% was seen in the latter. No significance was found between the groups (P = 0.581). Expression of AQP in compensated cirrhotic patients is significantly higher than decompensated cirrhotic patients and is especially higher in cirrhotic patients with ascites than with no ascites. There is no relationship between the concentration of vasopressin and expression of AQP. Concentration of serum NOx is higher in cirrhotic patients than the control group and there is a positive association between the concentration of serum nitric oxide and AQP in urine. In conclusion, expression of AQP is increased in cirrhotic patients and is significantly higher in patients with ascites. There is a positive association between the expression of AQP and concentration of serum nitric oxide.
Authors:
Sook Hee Chung; Dae Won Jun; Kyung Tae Kim; Jeong Don Chae; Eun Kyoung Park; Byoung Kwan Son; Seong Hwan Kim; Yun Ju Jo; Young Sook Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-03
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  55     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-18     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1135-41     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, Eulji University School of Medicine, Eulji Hospital, 280-1 Hagye 1-dong, Nowon-gu, Seoul, 139-711, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aquaporin 2 / urine*
Biopsy
Female
Hepatic Encephalopathy / pathology,  urine
Humans
Liver / pathology
Liver Cirrhosis / classification,  pathology,  urine*
Liver Function Tests
Male
Middle Aged
Multivariate Analysis
Nitric Oxide / urine*
Vasopressins / urine*
Water-Electrolyte Balance / physiology*
Chemical
Reg. No./Substance:
0/AQP2 protein, human; 0/Aquaporin 2; 10102-43-9/Nitric Oxide; 11000-17-2/Vasopressins

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