Document Detail

Aquagenic wrinkling of the palms in cystic fibrosis and the cystic fibrosis carrier state: a case–control study.
MedLine Citation:
PMID:  20560957     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Aquagenic wrinkling of the palms (AWP) is hyperwrinkling occurring within 3 min of exposure to water. It is associated with cystic fibrosis (CF) and has been reported in a CF carrier.
OBJECTIVES: To ascertain if AWP is a sign of the CF carrier state and to test for an association between cystic fibrosis transmembrane regulator (CFTR) protein function and time to wrinkling.
METHODS: Twenty-one patients, 13 carriers and 15 controls were recruited. Hands were immersed in water and time to wrinkling was measured. An analysis of variance was performed with mean time to wrinkling as the dependent variable and CF status as the independent variable. Patients with a time to wrinkling of ≤ 3 min were defined as having AWP. A test of proportions was performed to assess if the proportion of patients with AWP varied between groups.
RESULTS: Mean time to wrinkling was 11 min in controls, 7 min in carriers and 2 min in patients with CF. AWP was not seen in controls, but occurred in 80% of patients with CF and 25% of carriers. There was a significant difference between groups (P < 0·001).
CONCLUSIONS: The study demonstrated that AWP is a sign of both CF and the carrier state. It suggests that time to wrinkling decreases with decreased CFTR protein function. Patients presenting with AWP should be offered screening for both CF and the carrier state.
R Gild; C D Clay; S Morey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  163     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-03     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1082-4     Citation Subset:  IM    
Department of Dermatology, Princess Alexandra Hospital, Woolloongabba, Brisbane, Qld 4102, Australia.
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MeSH Terms
Analysis of Variance
Case-Control Studies
Child, Preschool
Cystic Fibrosis / diagnosis,  genetics,  physiopathology*
Cystic Fibrosis Transmembrane Conductance Regulator / physiology
Middle Aged
Skin Aging*
Time Factors
Water / adverse effects*
Young Adult
Reg. No./Substance:
126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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