Document Detail


Aqabamycins A-G: novel nitro maleimides from a marine Vibrio species: II. Structure elucidation.
MedLine Citation:
PMID:  20431615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The structures of secondary metabolites with antibacterial and cytotoxic activities produced by a marine Vibrio strain from the Red Sea were elucidated. Aqabamycin A (1a) and seven further nitro-substituted maleimide derivates named aqabamycins B-G (1b-f and 2) were obtained together with 12 known metabolites, 3-nitro-1H-indazole (3), indazole-3-carbaldehyde (4), 3-nitro-4-hydroxycinnamic acid, 4-hydroxycinnamic acid, 3-nitro-4-hydroxybenzaldehyde, phenyl-2-bis-indolylmethane (5a), turbomycin B (5b), vibrindole A (6), phenylacetic acid, 3-hydroxybenzoic acid, benzoic acid and 1,4-dithiane (7). Some of the known metabolites (for example, 3, 4 and 7) are described in this study for the first time as natural products. Their structures were elucidated based on 1D and 2D NMR, MS spectra and by comparison with synthetic material.
Authors:
Clarisse Blandine Fotso Fondja Yao; Wael Al Zereini; Serge Fotso; Heidrun Anke; Hartmut Laatsch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-30
Journal Detail:
Title:  The Journal of antibiotics     Volume:  63     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM    
Affiliation:
Institute for Organic and Biomolecular Chemistry, Georg-August University Göttingen, Göttingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / chemistry*,  isolation & purification
Chromatography, High Pressure Liquid
Magnetic Resonance Spectroscopy
Maleimides / isolation & purification*,  pharmacology
Structure-Activity Relationship
Vibrio / metabolism*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Maleimides; 0/aqabamycin A; 0/aqabamycin B; 0/aqabamycin C; 0/aqabamycin D; 0/aqabamycin E; 0/aqabamycin F; 0/aqabamycin G

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