| Aptasensors for biosecurity applications. | |
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MedLine Citation:
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PMID: 17548236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleic acid (aptasensors) have found steadily increased utility and application over the past decade. In particular, aptamers have been touted as a valuable complement to and, in some cases, replacement for antibodies owing to their structural and functional robustness as well as their ease in generation and synthesis. They are thus attractive for biosecurity applications (e.g. pathogen detection) and are especially well suited because their in vitro generation process does not require infection of any host systems. Herein we provide a brief overview of the aptamers generated against pathogens and toxins over the past few years. In addition, a few recently described detection platforms using aptamers and potentially suitable applications for biosecurity will be discussed. |
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Authors:
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Nicholas O Fischer; Theodore M Tarasow; Jeffrey B-H Tok |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2007-06-04 |
Journal Detail:
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Title: Current opinion in chemical biology Volume: 11 ISSN: 1367-5931 ISO Abbreviation: Curr Opin Chem Biol Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-26 Completed Date: 2007-09-17 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 9811312 Medline TA: Curr Opin Chem Biol Country: England |
Other Details:
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Languages: eng Pagination: 316-28 Citation Subset: IM |
Affiliation:
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BioSecurity and NanoSciences Laboratory, Chemistry, Materials & Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aptamers, Nucleotide
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chemistry* Base Sequence Biosensing Techniques* Ligands Nucleic Acid Conformation Security Measures* |
| Grant Support | |
ID/Acronym/Agency:
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AI065359/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aptamers, Nucleotide; 0/Ligands |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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