| Aptamers as therapeutics. | |
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MedLine Citation:
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PMID: 20592747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleic acid aptamers can be selected from pools of random-sequence oligonucleotides to bind a wide range of biomedically relevant proteins with affinities and specificities that are comparable to antibodies. Aptamers exhibit significant advantages relative to protein therapeutics in terms of size, synthetic accessibility and modification by medicinal chemistry. Despite these properties, aptamers have been slow to reach the marketplace, with only one aptamer-based drug receiving approval so far. A series of aptamers currently in development may change how nucleic acid therapeutics are perceived. It is likely that in the future, aptamers will increasingly find use in concert with other therapeutic molecules and modalities. |
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Authors:
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Anthony D Keefe; Supriya Pai; Andrew Ellington |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature reviews. Drug discovery Volume: 9 ISSN: 1474-1784 ISO Abbreviation: Nat Rev Drug Discov Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-07-15 Revised Date: 2010-08-25 |
Medline Journal Info:
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Nlm Unique ID: 101124171 Medline TA: Nat Rev Drug Discov Country: England |
Other Details:
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Languages: eng Pagination: 537-50 Citation Subset: IM |
Affiliation:
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X-Chem Incorporated, 100 Beaver Street,Waltham, Massachusetts 02453, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aptamers, Nucleotide / chemistry, therapeutic use*, toxicity DNA / chemistry, therapeutic use Drug Discovery Drug Evaluation, Preclinical Genetic Techniques Humans Ligands Nucleic Acid Conformation RNA / chemistry, therapeutic use RNA, Small Interfering / therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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R01GM077040/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aptamers, Nucleotide; 0/Ligands; 0/RNA, Small Interfering; 63231-63-0/RNA; 9007-49-2/DNA |
| Comments/Corrections | |
Erratum In:
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Nat Rev Drug Discov. 2010 Aug;9(8):660 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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