Document Detail


Aptamer-capped Multifunctional Mesoporous Strontium Hydroxyapatite Nanovehicle for Cancer Cell Responsive Drug Delivery and Imaging.
MedLine Citation:
PMID:  23140615     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A novel cancer cells-triggered controlled-release gadolinium-doped luminescent and mesoporous strontium hydroxyapatite nanorods (designated as Gd:SrHap nanorods) system using cell-type-specific aptamers as caps has been constructed. Aptamers behave as a dual-functional molecular that they act as not only a lid but also a targeted molecular which can be used as an effective way to therapeutically special cancer cells. After incubated with cancer cells, for example MCF-7 cells, the doxorubicin loaded and aptamer-capped Gd:SrHap nanorods (designated as Gd:SrHap-Dox-aptamer) can be internalized into MCF-7 cells resulting in the pore opening and drug releasing. Furthermore, the high biocompatibility and biodegradability Gd:SrHap nanorods with blue autofluorescence and paramagnetism could serve as a good contrast agent of targeting fluorescence and magnetic resonance imaging (MRI). We envision that this Gd:SrHap system could play a significant role in developing new generations of site-selective, controlled-release delivery, and interactive sensory nanodevices.
Authors:
Zhenhua Li; Zhen Liu; Meili Yin; Xinjian Yang; Qinghai Yuan; Jinsong Ren; Xiaogang Qu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Biomacromolecules     Volume:  -     ISSN:  1526-4602     ISO Abbreviation:  Biomacromolecules     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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