Document Detail

Aprotinin and induction of sarcoma with methylcholanthrene in rats
MedLine Citation:
PMID:  304712     Owner:  NLM     Status:  MEDLINE    
Considering the immunodepressive properties of aprotinine, the influence of this protease inhibitor on the induction of methylcholanthrene sarcoma in rats has been investigated. The results of the investigation showed that aprotinine failed to modify the experimental tumour induction process. This observation provides further confirmation that immunodepression is not a position to favour the growth of a tumour as a result of chemically induced oncogenesis.
G Laurentaci; D Dioguardi; M Pascone
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Archivio per le scienze mediche     Volume:  134     ISSN:  0004-0312     ISO Abbreviation:  Arch Sci Med (Torino)     Publication Date:    1977 Jul-Sep
Date Detail:
Created Date:  1978-03-21     Completed Date:  1978-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372451     Medline TA:  Arch Sci Med (Torino)     Country:  ITALY    
Other Details:
Languages:  ita     Pagination:  275-81     Citation Subset:  IM    
Vernacular Title:
Aprotinina ed induzione del sarcoma da metilcolantrene nel ratto.
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MeSH Terms
Aprotinin / pharmacology*
Sarcoma, Experimental / chemically induced*,  immunology
Reg. No./Substance:
56-49-5/Methylcholanthrene; 9087-70-1/Aprotinin

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