Document Detail

Aprotinin in the management of coagulopathy associated with amniotic fluid embolus.
MedLine Citation:
PMID:  16715609     Owner:  NLM     Status:  MEDLINE    
Amniotic fluid embolus, also known as anaphylactoid syndrome of pregnancy is a rare complication of pregnancy. When it occurs, the maternal mortality rate may be as high as 86%, and in survivors, the morbidity rate may be just as high. Hallmark clinical features include maternal cardiovascular collapse with disseminated intravascular coagulation, and fetal distress. Management centers on strategies to improve oxygenation, support circulation, and correct the coagulopathy. We report the case of a patient who developed amniotic fluid embolus and was effectively managed with aprotinin to control the coagulopathy associated with this devastating complication of pregnancy.
Jeffrey Stroup; Davin Haraway; J Martin Beal
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmacotherapy     Volume:  26     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-22     Completed Date:  2006-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  689-93     Citation Subset:  IM    
University of Oklahoma College of Pharamcy, Tulsa, 74135, USA.
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MeSH Terms
Aprotinin / therapeutic use*
Blood Cell Count
Blood Coagulation Disorders / drug therapy*,  etiology*
Blood Coagulation Tests
Embolism, Amniotic Fluid / physiopathology*
Hemostatics / therapeutic use*
Isotonic Solutions / therapeutic use
Plasma Substitutes / therapeutic use
Uterus / physiopathology
Reg. No./Substance:
0/Hemostatics; 0/Isotonic Solutions; 0/Plasma Substitutes; 0/crystalloid solutions; 9087-70-1/Aprotinin

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