Document Detail

Aprotinin in cardiac surgery: a review of conventional and novel mechanisms of action.
MedLine Citation:
PMID:  17898372     Owner:  NLM     Status:  MEDLINE    
Induction of the coagulation and inflammatory cascades can cause multiorgan dysfunction after cardiopulmonary bypass (CPB). In light of these observations, strategies that can stabilize the coagulation process as well as attenuate the inflammatory response during and after cardiac surgery are important. Aprotinin has effects on hemostasis. In addition, aprotinin may exert multiple biologically relevant effects in the context of cardiac surgery and CPB. For example, it decreases neutrophil and macrophage activation and chemotaxis, attenuates release and activation of proinflammatory cytokines, and reduces oxidative stress. Despite these perceived benefits, the routine use of aprotinin in cardiac surgery with CPB has been called into question. In this review, we examined this controversial drug by discussing the classical and novel pathways in which aprotinin may be operative in the context of cardiac surgery.
Matthew D McEvoy; Scott T Reeves; J G Reves; Francis G Spinale
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  105     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-27     Completed Date:  2007-10-29     Revised Date:  2008-05-01    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  949-62     Citation Subset:  AIM; IM    
Department of Anesthesiology and Perioperative Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
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MeSH Terms
Aprotinin / adverse effects,  chemistry,  pharmacology,  therapeutic use*
Brain / drug effects
Cardiac Surgical Procedures*
Cardiopulmonary Bypass
Heart / drug effects
Hemostatics / adverse effects,  chemistry,  pharmacology,  therapeutic use*
Kidney / drug effects
Lung / drug effects
Reg. No./Substance:
0/Hemostatics; 9087-70-1/Aprotinin
Comment In:
Anesth Analg. 2008 May;106(5):1593   [PMID:  18420895 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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