| Aprotinin in cardiac surgery: a review of conventional and novel mechanisms of action. | |
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MedLine Citation:
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PMID: 17898372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Induction of the coagulation and inflammatory cascades can cause multiorgan dysfunction after cardiopulmonary bypass (CPB). In light of these observations, strategies that can stabilize the coagulation process as well as attenuate the inflammatory response during and after cardiac surgery are important. Aprotinin has effects on hemostasis. In addition, aprotinin may exert multiple biologically relevant effects in the context of cardiac surgery and CPB. For example, it decreases neutrophil and macrophage activation and chemotaxis, attenuates release and activation of proinflammatory cytokines, and reduces oxidative stress. Despite these perceived benefits, the routine use of aprotinin in cardiac surgery with CPB has been called into question. In this review, we examined this controversial drug by discussing the classical and novel pathways in which aprotinin may be operative in the context of cardiac surgery. |
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Authors:
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Matthew D McEvoy; Scott T Reeves; J G Reves; Francis G Spinale |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 105 ISSN: 1526-7598 ISO Abbreviation: Anesth. Analg. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-27 Completed Date: 2007-10-29 Revised Date: 2008-05-01 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
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Languages: eng Pagination: 949-62 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology and Perioperative Medicine, Medical University of South Carolina, Charleston, South Carolina, USA. mcevoymd@musc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aprotinin
/
adverse effects,
chemistry,
pharmacology,
therapeutic use* Brain / drug effects Cardiac Surgical Procedures* Cardiopulmonary Bypass Heart / drug effects Hemostasis Hemostatics / adverse effects, chemistry, pharmacology, therapeutic use* Humans Kidney / drug effects Lung / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Hemostatics; 9087-70-1/Aprotinin |
| Comments/Corrections | |
Comment In:
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Anesth Analg. 2008 May;106(5):1593
[PMID:
18420895
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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