| Aprotinin improves pulmonary function during reperfusion in an isolated lung model. | |
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MedLine Citation:
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PMID: 11093508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We hypothesized that the use of aprotinin would ameliorate the reperfusion injury observed after lung transplantation because of a reduction in the inflammatory response. METHODS: We used an isolated, whole blood-perfused, ventilated rabbit lung model to study the effects of aprotinin during reperfusion. The control animals (group A, n = 8) underwent lung harvest after pulmonary arterial prostaglandin E1 injection and Euro-Collins preservation flush before saline storage for 18 hours at 4 degrees C. The experimental groups received either a low dose (3,000 KIU/mL; group B, n = 8) or a high dose (10,000 KIU/mL; group C, n = 8) of aprotinin added to the pulmonary flush before storage. Each lung was reperfused at 37 degrees C at a rate of 60 mL/min. RESULTS: The arterial partial pressure of oxygen values of group B (low-dose aprotinin) were significantly higher than those of group A (control) after 10 minutes of reperfusion (69.19 +/- 5.69 mm Hg versus 264.30 +/- 48.59 mm Hg, respectively, p = 0.001). Similar results were recorded at 20 and at 30 minutes of reperfusion. Similarly, after 10 minutes of reperfusion, the differences between groups A and C were 69.19 +/- 5.69 mm Hg versus 235.91 +/- 28.63 mm Hg, respectively (p = 0.001). CONCLUSIONS: The addition of aprotinin to the Euro-Collins pulmonary flush significantly improves arterial oxygenation in the early reperfusion period. The enhanced oxygenation suggests that aprotinin may offer protection against early reperfusion injury. |
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Authors:
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M A Mathias; C G Tribble; J F Dietz; R P Nguyen; K S Shockey; J A Kern; I L Kron |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 70 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-01-05 Completed Date: 2001-01-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1671-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Virginia Health Sciences Center, Charlottesville 22908, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aprotinin / administration & dosage, pharmacology* Hypertonic Solutions Lung / physiology* Rabbits Reperfusion* Reperfusion Injury / prevention & control Serine Proteinase Inhibitors / administration & dosage, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL56093/HL/NHLBI NIH HHS; T32 HL07849/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Euro-Collins' solution; 0/Hypertonic Solutions; 0/Serine Proteinase Inhibitors; 9087-70-1/Aprotinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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