| Aprotinin decreases blood loss in patients undergoing revision or bilateral total hip arthroplasty. | |
| | |
MedLine Citation:
|
PMID: 7529467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Two recent studies have shown decreased blood loss in patients given aprotinin undergoing primary hip replacement surgery. Because patients undergoing bilateral (bTHA) or revision total hip arthroplasty (rTHA) suffer more blood loss than those undergoing primary THA, we studied consecutive patients undergoing bTHA or rTHA who were randomized to receive either a blinded solution of 3.8 x 10(6) Kallikrein inactivation units (KIU) aprotinin (n = 29) or placebo (n = 24) throughout the surgical procedure. Total blood loss, measured as intraoperative suction losses, weight of sponges, and postoperative volumetric drainage, was compared between groups. Aprotinin patients had significantly less total blood loss 1498 +/- 110 mL (mean +/- SEM) versus 2096 +/- 223 (P = 0.022), and transfused patients in the aprotinin group received fewer packed red blood cells than placebo-treated patients (confidence interval for the difference -1.69, -0.07). In addition, assessment of biochemical markers of hepatic and renal function did not disclose any clinically important differences between groups. Patients were also assessed for development of deep venous thrombosis (DVT) by preoperative and predischarge bilateral lower limb compression ultrasound. None of the aprotinin-treated patients and three placebo-treated patients demonstrated DVT. Unless this trend for decreased DVT with aprotinin can be confirmed, it is questionable whether the slight reduction in blood loss justifies routine use of this expensive drug. |
| | |
Authors:
|
J M Murkin; N A Shannon; R B Bourne; C H Rorabeck; M Cruickshank; G Wyile |
Related Documents
:
|
19632407 - Miniaturized cardiopulmonary bypass and acute kidney injury in coronary artery bypass g... 19583607 - Influence of methylprednisolone on levels of neuron-specific enolase in cardiac surgery... 8904327 - The effect of low-dose epsilon-aminocaproic acid on patients following coronary artery ... 2658177 - Ranitidine prevents postoperative transfusion-induced depression of delayed hypersensit... 14702447 - Influence of helicobacter pylori eradication on gastroesophageal reflux symptoms and ep... 12704327 - A short-term experience with the tirone david i valve sparing operation for the treatme... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anesthesia and analgesia Volume: 80 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1995 Feb |
Date Detail:
|
Created Date: 1995-02-09 Completed Date: 1995-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 343-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anaesthesia, University Hospital, University of Western Ontario, London, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aprotinin / blood, therapeutic use* Blood Loss, Surgical / prevention & control* Double-Blind Method Female Hip Prosthesis* Humans Male Reoperation Thrombosis / prevention & control, therapy, ultrasonography |
| Chemical | |
Reg. No./Substance:
|
9087-70-1/Aprotinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The fate of somitocoele cells in avian embryos.
Next Document: Comparative effects of small and large aprotinin doses on bleeding during orthotopic liver transplan...