| Apricot carotenoids possess potent anti-amyloidogenic activity in vitro. | |
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MedLine Citation:
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PMID: 22043804 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Alzheimer's disease (AD) is the most common form of dementia and is characterized by the progressive accumulation of amyloid β protein (Aβ) in areas of the brain. There has been an increased interest in screening for food-grade anti-amyloidogenic compounds in food stuffs. The purpose of this study was to screen and identify the bioactive compounds with amyloidogenicity in apricot fruits using synthetic Aβ<sub>1-42</sub>. The anti-amyloidogenicity was investigated using thioflavin T fluorescence assay, electron microscopy, and dot-blotting analysis. The carotenoid fraction from apricot showed strong inhibitory effects against oligomers and fibrils formation of Aβ and fibril-destabilizing effects. Among the peaks in HPLC chromatogram, lutein showed the strongest inhibitory effect on Aβ fibril formation. The inhibitory effect was dependent on the number and portion of hydroxyl groups on both sides of carotenoids. These findings suggest that lutein in fruits may be useful as preventive agents for amyloid-associated diseases.<sub> |
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Authors:
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Shigeru Katayama; Hirofumi Ogawa; Soichiro Nakamura |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-1 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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