Document Detail

Apramides A-G, novel lipopeptides from the marine cyanobacterium Lyngbya majuscula.
MedLine Citation:
PMID:  10978206     Owner:  NLM     Status:  MEDLINE    
Six new metabolites have been isolated from a lyngbyastatin 2-producing strain of the marine cyanobacterium Lyngbya majuscula collected at Apra Harbor, Guam, and their structures elucidated. These linear lipopeptides have been assigned the trivial names apramides A-F (1-6). From a more recent collection of this cyanobacterium, a structurally related compound, apramide G (7), has been found instead of apramides A-F (1-6). Structure elucidation of the lipopeptides 1-7 is based on spectroscopic techniques and chiral chromatography of hydrolysis products. The apramides appear as NMR-spectroscopically distinguishable conformers in solution, and this has been ascribed to the presence of a thiazole-containing modified amino acid unit.
H Luesch; W Y Yoshida; R E Moore; V J Paul
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of natural products     Volume:  63     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-10-31     Completed Date:  2000-10-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1106-12     Citation Subset:  IM    
Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
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MeSH Terms
Chromatography, Gel
Chromatography, High Pressure Liquid
Cyanobacteria / chemistry*
Lipoproteins / chemistry,  isolation & purification*
Magnetic Resonance Spectroscopy
Optical Rotation
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Grant Support
Reg. No./Substance:

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