| Approximate dimensions of membrane lesions produced by streptolysin S and streptolysin O. | |
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MedLine Citation:
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PMID: 6299345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Membrane lesions produced by the streptococcal membranolysins streptolysin S and streptolysin O were investigated. Escape of labeled marker molecules of various sizes from resealed sheep erythrocyte ghosts treated with the toxins for 30 min allowed estimation of the sizes of the primary channels formed. Streptolysin S formed lesions ranging in size up to 45 A in diameter, and even high toxin concentrations did not result in larger channels. The lesions produced by streptolysin O exceeded 128 A in diameter. Kinetics experiments demonstrated that the primary streptolysin O lesions were formed rapidly (1-2 min), but release of marker molecules from streptolysin S-treated vesicles began only after a 5-15-min lag period. Label release from large unilamellar liposomes treated with streptolysin S suggested that membrane fluidity does not affect the size of the streptolysin S lesions. |
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Authors:
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L Buckingham; J L Duncan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 729 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1983 Mar |
Date Detail:
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Created Date: 1983-05-05 Completed Date: 1983-05-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 115-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Proteins Erythrocyte Membrane / drug effects, ultrastructure* Erythrocytes / ultrastructure* Ion Channels / drug effects Kinetics Liposomes Sheep Streptolysins / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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AI-11644/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Ion Channels; 0/Liposomes; 0/Streptolysins; 0/streptolysin O; 0/streptolysin S |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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