Document Detail

Approximate dimensions of membrane lesions produced by streptolysin S and streptolysin O.
MedLine Citation:
PMID:  6299345     Owner:  NLM     Status:  MEDLINE    
Membrane lesions produced by the streptococcal membranolysins streptolysin S and streptolysin O were investigated. Escape of labeled marker molecules of various sizes from resealed sheep erythrocyte ghosts treated with the toxins for 30 min allowed estimation of the sizes of the primary channels formed. Streptolysin S formed lesions ranging in size up to 45 A in diameter, and even high toxin concentrations did not result in larger channels. The lesions produced by streptolysin O exceeded 128 A in diameter. Kinetics experiments demonstrated that the primary streptolysin O lesions were formed rapidly (1-2 min), but release of marker molecules from streptolysin S-treated vesicles began only after a 5-15-min lag period. Label release from large unilamellar liposomes treated with streptolysin S suggested that membrane fluidity does not affect the size of the streptolysin S lesions.
L Buckingham; J L Duncan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  729     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  115-22     Citation Subset:  IM    
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MeSH Terms
Bacterial Proteins
Erythrocyte Membrane / drug effects,  ultrastructure*
Erythrocytes / ultrastructure*
Ion Channels / drug effects
Streptolysins / pharmacology*
Grant Support
Reg. No./Substance:
0/Bacterial Proteins; 0/Ion Channels; 0/Liposomes; 0/Streptolysins; 0/streptolysin O; 0/streptolysin S

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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