Document Detail

Appropriate indications for venous duplex scanning based on D-dimer assay.
MedLine Citation:
PMID:  11981689     Owner:  NLM     Status:  MEDLINE    
Because of the rapid growth in requests for lower extremity duplex scanning, we tested a new rapid D-dimer assay method, the Miniquant test, for its ability to rule out deep vein thrombosis (DVT) in patient subgroups with the following risk factors: malignancy, postoperative state, and cellulitis. One hundred twenty-six consecutive patients with suspected DVT underwent clinical assessment, D-dimer testing with quantitative Miniquant D-dimer assay, and duplex scanning according to standard criteria for the diagnosis of DVT. Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were calculated versus duplex scanning for the various risk factor subgroups. Our results showed that the Miniquant D-dimer assay is useful preselection procedure (high NPV) in selected patient subgroups with suspected proximal DVT, including patients with cellulitis and those without malignancy or postoperative state. This preselection procedure has the potential for avoiding a large proportion of unnecessary duplex scanning, thus saving time and reducing costs.
D Shitrit; H Levi; M Huerta; B Rudensky; A Bargil-Shitrit; N Gutterer
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Publication Detail:
Type:  Journal Article     Date:  2002-05-02
Journal Detail:
Title:  Annals of vascular surgery     Volume:  16     ISSN:  0890-5096     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-08-01     Completed Date:  2002-09-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  304-8     Citation Subset:  IM    
Department of Internal Medicine and Pulmonary Institute, Shaare Zedek Medical Center, Jerusalem, Israel.
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MeSH Terms
Cellulitis / blood
Fibrin Fibrinogen Degradation Products / analysis*
Middle Aged
Sensitivity and Specificity
Ultrasonography, Doppler, Duplex*
Venous Thrombosis / diagnosis*,  ultrasonography*
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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