Document Detail

Appropriate and inappropriate neuroendocrine products in pulmonary tumourlets.
MedLine Citation:
PMID:  2145655     Owner:  NLM     Status:  MEDLINE    
Pulmonary tumourlets are focal aggregates of neuroendocrine cells that occur in the periphery of the lung and may be associated with chronic inflammation and scarring. Six such lesions were seen in five lungs from a series of 35 pairs of lungs studied at necropsy. All were immunoreactive for neurone-specific enolase, protein gene product 9.5, and a range of neuroendocrine products. Of the peptides found in neuroendocrine cells in normal human lungs, gastrin releasing peptide was present in all tumourlets and calcitonin in all but one; none contained leucineenkephalin. Of a series of peptide and protein hormones not present in the neuroendocrine cells of healthy human lungs, growth hormone was present in all six tumourlets and adrenocorticotrophin in two. Identical patterns of peptide expression were displayed by neuroendocrine cells in the airway associated with the tumourlets in two cases. Such cells were increased in number and abnormally clustered. Aberrant expression of peptides might accompany the morphological changes in the pulmonary neuroendocrine cells seen in diseased lungs, their florid focal proliferation occasionally resulting in the formation of a tumourlet.
J Gosney; A R Green; W Taylor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thorax     Volume:  45     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-11-19     Completed Date:  1990-11-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  679-83     Citation Subset:  IM    
Department of Pathology, University of Liverpool.
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MeSH Terms
Gastrin-Releasing Peptide
Gastrointestinal Hormones / analysis
Hormones / analysis*
Lung / metabolism,  pathology*
Lung Neoplasms / metabolism,  pathology*
Neuropeptides / analysis
Neurosecretory Systems / metabolism,  pathology*
Peptides / analysis*
Phosphopyruvate Hydratase / analysis
Tumor Markers, Biological / analysis
Ubiquitin Thiolesterase
Reg. No./Substance:
0/Gastrointestinal Hormones; 0/Hormones; 0/Neuropeptides; 0/Peptides; 0/Tumor Markers, Biological; 80043-53-4/Gastrin-Releasing Peptide; EC Thiolesterase; EC Hydratase

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