Document Detail


Approaching Ewing sarcoma.
MedLine Citation:
PMID:  20624127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although Ewing sarcoma represents a rare malignancy of childhood and adolescence, it has attracted the attention of an increasing number of excellent researchers. With a tumor-specific EWS-ETS translocation coding for a transcription factor, which obviously profoundly modifies the intracellular signaling network, this rare malignancy opens insights in pathological gene and protein regulation. Despite decades of basic and translational research, clinical improvement has not yet been modulated by novel targeted therapies, but is produced by well-designed multimodal treatments. By using these multimodal treatment approaches, which always include chemotherapy and local treatment, the prognosis has been improved by up to 70%. For more than 10 years, the survival curves have plateaued at a relatively high level. However, a 30% relapse rate is still unacceptably high, considering that the prognosis after relapse is fatal for most patients. Therefore, novel treatment approaches are urgently required. This article provides an overview of the Ewing sarcoma research of the past few years; while not claiming to be complete, it offers a view on putative strategies with translational potential.
Authors:
Uta Dirksen; Heribert Jürgens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Future oncology (London, England)     Volume:  6     ISSN:  1744-8301     ISO Abbreviation:  Future Oncol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-13     Completed Date:  2010-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256629     Medline TA:  Future Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1155-62     Citation Subset:  IM    
Affiliation:
Pediatric Hematology & Oncology, Albert-Schweitzer Str. 33, 48149 Münster, Germany.
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MeSH Terms
Descriptor/Qualifier:
Gene Expression Regulation, Neoplastic
Humans
RNA-Binding Protein EWS / genetics,  metabolism
Research / trends
Sarcoma, Ewing's / physiopathology*,  therapy*
Stem Cell Transplantation
Translational Research
Chemical
Reg. No./Substance:
0/RNA-Binding Protein EWS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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