Document Detail


Approaches to understanding adaptations of skin color variation by detecting gene-environment interactions.
MedLine Citation:
PMID:  21080816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetic and environmental factors are both part of an elaborate feedback mechanism whereby the human adaptive form reacts to environmental stimuli via internal adjustments. Human survival may ultimately depend on understanding two important components of future environmental adaptation. First, we must elucidate the dynamics of the human genome underpinning the complex human phenotype. Second, we must understand how the environment pressures and affects the genome, helping to determine human traits. This article reviews current approaches to detecting the natural selection of skin color variation in human populations. We include statistical methods for clarifying gene-environment interactions applicable to the interactions with UV radiation levels. We recommend spatial data mining as an efficient approach that applies environmental association rules, extending our knowledge of adaptation to the environment.
Authors:
Sumiko Anno; Kazuhiko Ohshima; Takashi Abe
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of molecular diagnostics     Volume:  10     ISSN:  1744-8352     ISO Abbreviation:  Expert Rev. Mol. Diagn.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-18     Completed Date:  2011-05-20     Revised Date:  2011-06-09    
Medline Journal Info:
Nlm Unique ID:  101120777     Medline TA:  Expert Rev Mol Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  987-91     Citation Subset:  IM    
Affiliation:
Shibaura Institute of Technology, 3-7-5 Toyosu, Koto-ku, Tokyo 135-8548, Japan. annou@sic.shibaura-it.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Biological / genetics*
Environment
Gene Expression
Genetic Variation*
Humans
Phenotype
Polymorphism, Single Nucleotide
Selection, Genetic
Skin Pigmentation / genetics*
Ultraviolet Rays
Comments/Corrections
Erratum In:
Expert Rev Mol Diagn. 2011 Mar;11(2):238-40

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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