Document Detail

Approaches to the risk assessment of fumonisins in corn-based foods in Canada.
MedLine Citation:
PMID:  8850633     Owner:  NLM     Status:  MEDLINE    
The presence of fumonisins and associated mycotoxins from Fusarium moniliforme in corn-based foods has recently become a concern in North America and elsewhere. Monitoring of various corn based foods and food commodities for fumonisins is ongoing in both the USA and Canada, and the results can be used for preliminary exposure assessments. The role of Fusarium moniliforme and the fumonisins in some diseases of livestock has been established. Considerable information is available on the mechanism of action of the fumonisins. With the availability of increased quantities of pure fumonisins, several subchronic toxicity studies, designed to establish dose response characteristics in rodents have now been completed. However, since concerns about the chronic toxicity of the fumonisins have not yet been adequately addressed, a tolerable daily intake cannot be established at this time. With the information at hand it is, nevertheless, possible to arrive at an interim risk assessment, which can be used to make interim risk management decisions. A total of 361 samples, covering 4 years of a Canadian survey, have been analyzed to date. Of these, 64 contained > or = 0.1 micrograms/g fumonisin B1, and 10 contained > or = 1 microgram/g. The 'all persons' estimate for the intake of fumonisins from these foods was < 0.089 micrograms/kg bw for 5-11 year-old children, and lower for other age groups. Based on an assessment of the available information on the toxicity of fumonisins, it can be concluded that these estimated intakes are unlikely to pose a health risk.
T Kuiper-Goodman; P M Scott; N P McEwen; G A Lombaert; W Ng
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  392     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-11     Completed Date:  1996-12-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  369-93     Citation Subset:  IM    
Health Canada, Food Directorate, Ottawa, Ontario.
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MeSH Terms
Carcinogens, Environmental
Food Contamination*
Mycotoxins / administration & dosage,  analysis*,  toxicity
Neoplasms / chemically induced
Risk Assessment
Zea mays / chemistry*
Reg. No./Substance:
0/Carcinogens, Environmental; 0/Fumonisins; 0/Mycotoxins; 116355-83-0/fumonisin B1; 116355-84-1/fumonisin B2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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