| Approaches to refractory hypoxemia in acute respiratory distress syndrome: current understanding, evidence, and debate. | |
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MedLine Citation:
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PMID: 22008398 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) cause substantial morbidity and mortality despite our improved understanding of lung injury, advancements in the application of lung-protective ventilation, and strategies to prevent ventilator-induced lung injury. Severe refractory hypoxemia may develop in a subset of patients with severe ARDS. We review several approaches referred to as "rescue" therapies for severe hypoxemia, including lung-recruitment maneuvers, ventilation modes, prone positioning, inhaled vasodilator therapy, and the use of extracorporeal membrane oxygenation. Each shows evidence for improving oxygenation, though each has associated risks, and no single therapy has proven superior in the management of severe hypoxemia. Importantly, increased survival with these strategies has not been clearly established. |
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Authors:
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Stephen R Collins; Randal S Blank |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Respiratory care Volume: 56 ISSN: 0020-1324 ISO Abbreviation: Respir Care Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7510357 Medline TA: Respir Care Country: United States |
Other Details:
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Languages: eng Pagination: 1573-82 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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