Document Detail


Approaches to assess the oral bioaccessibility of persistent organic pollutants: a critical review.
MedLine Citation:
PMID:  17490715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oral bioaccessibility, also known as in vitro gastrointestinal extraction or the physiologically based extraction test (PBET), is an important tool when assessing the risk to humans from persistent organic pollutants (POPs) (and metals). The approach seeks to mimic the processes of human food digestion and thereby assess the bioavailability of POPs (and metals) from materials consumed either accidentally or intentionally in the diet. In vitro conditions are created to simulate various actions in the stomach and intestines (although some methods also include the mouth compartment). This paper reviews the current status of oral bioaccessibility with respect to the release of POPs from soil and related samples of environmental importance. Particular emphasis is placed on the parameters that influence gastrointestinal extraction including gastric and intestinal pH, enzymes, bile salts, food constituents and residence time. In addition, important developments in the use of in vitro gastrointestinal extraction are highlighted. These developments include the use of epithelial Caco-2 cells to mimic the intestinal cell lining, the potential for biotransformation of POPs into estrogenic metabolites as a result of colon microbiota, and the use of in vivo studies to validate existing approaches.
Authors:
John R Dean; Renli Ma
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-05-08
Journal Detail:
Title:  Chemosphere     Volume:  68     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  1399-407     Citation Subset:  IM    
Affiliation:
Biomolecular and Biomedical Research Centre, School of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Biological Availability
Biotransformation
Environmental Pollutants / pharmacokinetics*
Gastrointestinal Tract / metabolism*,  physiology
Humans
Models, Biological*
Organic Chemicals / pharmacokinetics*
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Organic Chemicals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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