| Approaches to the pharmacological modulation of plasmacytoid dendritic cells. | |
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MedLine Citation:
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PMID: 21476966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human plasmacytoid dendritic cells (pDC) are crucial for the modulation of adaptive immune responses in the course of neoplastic, viral and autoimmune diseases. In several of these disorders deregulated pDC-derived interferon-α (IFN-α), a key cytokine produced by pDC, plays a central role. Apart from IFN-α, pDC can produce a variety of other mediators, which are involved in immunological cross-talk. The most recently discovered are the cytotoxic serine protease granzyme B (GrB) and indoleamine 2,3-dioxygenase, which have been described to be involved in the suppression of effector T cell responses. Here we review the regulation of pDC function by a variety of immunomodulatory agents, which may be developed as future candidates for the therapy of a variety of diseases. Moreover, we introduce the novel concept of enhancing immune responses after vaccination in poor responders by increasing pDC-derived IFN-α and simultaneously inhibiting pDC-derived GrB secretion. Finally we discuss potential approaches to abrogate pDC-mediated tolerance induction against tumors and viral infections. |
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Authors:
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Dorit Fabricius; Bernd Jahrsdörfer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Endocrine, metabolic & immune disorders drug targets Volume: 11 ISSN: 2212-3873 ISO Abbreviation: Endocr Metab Immune Disord Drug Targets Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-09-28 Revised Date: 2011-12-09 |
Medline Journal Info:
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Nlm Unique ID: 101269157 Medline TA: Endocr Metab Immune Disord Drug Targets Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 154-64 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Ulm, Ulm, Germany. dorit.fabricius@uni-ulm.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytotoxicity, Immunologic / drug effects, physiology Dendritic Cells / drug effects*, immunology* Humans Immunologic Factors / pharmacology*, therapeutic use Immunotherapy / methods, trends Inflammation Mediators / antagonists & inhibitors, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Immunologic Factors; 0/Inflammation Mediators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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