| Approaches to Diagnosing and Managing Anticoagulant-Related Bleeding. | |
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MedLine Citation:
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PMID: 23034830 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Anticoagulant therapy reduces deaths and disability in patients with or at risk of both arterial and venous thromboembolism. Highly effective antithrombotic therapies now exist that reduce the risk of both arterial thrombosis and venous thrombosis. Anticoagulant strategies include platelet inhibition, using a variety of potent platelet inhibitors, and antithrombotic therapy, designed to interfere with thrombosis by blocking activation of the coagulation cascade. All anticoagulants increase the risk of bleeding. Older antithrombotic agents have, in most cases, effective antidotes and well-developed (although perhaps not very evidence-based) treatment strategies. Newer anticoagulants, and most antiplatelet drugs, do not have effective antidotes or well-tested reversal strategies. This narrative review will provide advice on the diagnosis and management of anticoagulant bleeding with a particular focus on the antithrombotic drugs, including warfarin, heparin, and the novel agents. |
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Authors:
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Jennifer Goy; Mark Crowther |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-3 |
Journal Detail:
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Title: Seminars in thrombosis and hemostasis Volume: - ISSN: 1098-9064 ISO Abbreviation: Semin. Thromb. Hemost. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0431155 Medline TA: Semin Thromb Hemost Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. |
Affiliation:
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Department of Internal Medicine, Internal Medicine Residency Program, Residency Program Office, Hamilton, Ontario, Canada. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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