Document Detail

Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE study.
MedLine Citation:
PMID:  22127229     Owner:  NLM     Status:  MEDLINE    
Calorie restriction (CR) is a component of most weight loss interventions and a potential strategy to slow aging. Accurate determination of energy intake and %CR is critical when interpreting the results of CR interventions; this is most accurately achieved using the doubly labeled water method to quantify total energy expenditure (TEE). However, the costs and analytical requirements of this method preclude its repeated use in many clinical trials. Our aims were to determine 1) the optimal TEE assessment time points for quantifying average energy intake and %CR during long-term CR interventions and 2) the optimal approach for quantifying short-term changes in body energy stores to determine energy intake and %CR during 2-wk DLW periods. Adults randomized to a CR intervention in the multicenter CALERIE study underwent measurements of TEE by doubly labeled water and body composition at baseline and months 1, 3, and 6. Average %CR achieved during the intervention was 24.9 ± 8.7%, which was computed using an approach that included four TEE assessment time points (i.e., TEE(baseline, months 1, 3, and 6)) plus the 6-mo change in body composition. Approaches that included fewer TEE assessments yielded %CR values of 23.4 ± 9.0 (TEE(baseline,) months 3 and 6), 25.0 ± 8.7 (TEE(baseline,) months 1 and 6), and 20.9 ± 7.1% (TEE(baseline, month 6)); the latter approach differed significantly from approach 1 (P < 0.001). TEE declined 9.6 ± 9.9% within 2-4 wk of CR beginning and then stabilized. Regression of daily home weights provided the most reliable estimate of short-term change in energy stores. In summary, optimal quantification of energy intake and %CR during weight loss necessitates a TEE measurement within the first month of CR to capture the rapid reduction in TEE.
Susan B Racette; Sai Krupa Das; Manjushri Bhapkar; Evan C Hadley; Susan B Roberts; Eric Ravussin; Carl Pieper; James P DeLany; William E Kraus; James Rochon; Leanne M Redman;
Related Documents :
9354539 - Modified norwood operation for single left ventricle and ventriculoarterial discordance...
7609549 - Crinkling of epicardial defibrillator patches. a common and serious problem.
7379289 - Fontan procedure for tricuspid atresia.
20103339 - Current expectations for surgical repair of isolated ventricular septal defects.
12238839 - Fontan-type procedures: residual lesions and late interventions.
18652009 - Intracardiac echocardiography in patients with pacing and defibrillating leads: a feasi...
3282889 - Basilar artery disease--clinical outcome and doppler sonographical follow-up.
15057529 - Management of hardware infections following deep brain stimulation.
17229789 - A radiographic analysis of external apical root resorption of maxillary incisors during...
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-11-29
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  302     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-06     Completed Date:  2012-03-30     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E441-8     Citation Subset:  IM    
Washington University School of Medicine, St. Louis, MO 63108, USA.
Data Bank Information
Bank Name/Acc. No.:;  NCT00099138;  NCT00099151
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Composition
Body Mass Index
Body Weight
Caloric Restriction*
Energy Intake / physiology*
Energy Metabolism / physiology*
Middle Aged
Young Adult
Grant Support
M01-RR-00036/RR/NCRR NIH HHS; P30-DK-056341/DK/NIDDK NIH HHS; P60-DK-020579-30/DK/NIDDK NIH HHS; R00 HD060762/HD/NICHD NIH HHS; U01-AG-020478/AG/NIA NIH HHS; U01-AG-020480/AG/NIA NIH HHS; U01-AG-020487/AG/NIA NIH HHS; U01-AG022132/AG/NIA NIH HHS; UL1 TR000041/TR/NCATS NIH HHS
Andrew Deutsch / ; Paula J Geiselman / ; Frank Greenway / ; Leonie Heilbronn / ; Enette Larson-Meyer / ; Michael Lefebre / ; Marlene Most-Windhauser / ; Steven Smith / ; Cheryl H Gilhooly / ; Paul J Fuss / ; Gerard E Dallal / ; John O Holloszy / ; Hassan Arif / ; Ali Ehsani / ; Luigi Fontana / ; Samuel Klein / ; Christopher Koenig / ; Kathleen A Obert / ; Kenneth B Schechtman / ; Morgan Schram / ; Karen Steger-Mary / ; Richard I Stein / ; Dennis T Villareal / ; Laura Weber / ; Edward P Weiss / ; Connie Bales /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pyrrolidine dithiocarbamate enhances hepatic glycogen synthesis and reduces FoxO1-mediated gene tran...
Next Document:  Intake of branched-chain amino acids influences the levels of MAFbx mRNA and MuRF-1 total protein in...