Document Detail

Approaches for drug delivery with intracortical probes.
MedLine Citation:
PMID:  24101367     Owner:  NLM     Status:  Publisher    
Abstract Intracortical microprobes allow the precise monitoring of electrical and chemical signaling and are widely used in neuroscience. Microelectromechanical system (MEMS) technologies have greatly enhanced the integration of multifunctional probes by facilitating the combination of multiple recording electrodes and drug delivery channels in a single probe. Depending on the neuroscientific application, various assembly strategies are required in addition to the microprobe fabrication itself. This paper summarizes recent advances in the fabrication and assembly of micromachined silicon probes for drug delivery achieved within the EU-funded research project NeuroProbes. The described fabrication process combines a two-wafer silicon bonding process with deep reactive ion etching, wafer grinding, and thin film patterning and offers a maximum in design flexibility. By applying this process, three general comb-like microprobe designs featuring up to four 8-mm-long shafts, cross sections from 150×200 to 250×250 µm², and different electrode and fluidic channel configurations are realized. Furthermore, we discuss the development and application of different probe assemblies for acute, semichronic, and chronic applications, including comb and array assemblies, floating microprobe arrays, as well as the complete drug delivery system NeuroMedicator for small animal research.
Sven Spieth; Axel Schumacher; Fabian Trenkle; Olivia Brett; Karsten Seidl; Stanislav Herwik; Sebastian Kisban; Patrick Ruther; Oliver Paul; Arno A A Aarts; Hercules P Neves; P Dylan Rich; David E Theobald; Tahl Holtzman; Jeffrey W Dalley; Bram-Ernst Verhoef; Peter Janssen; Roland Zengerle
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-5
Journal Detail:
Title:  Biomedizinische Technik. Biomedical engineering     Volume:  -     ISSN:  1862-278X     ISO Abbreviation:  Biomed Tech (Berl)     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1262533     Medline TA:  Biomed Tech (Berl)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-13     Citation Subset:  -    
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