| An Approach towards the quantitative structure-activity relationships of caffeic acid and its derivatives. | |
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MedLine Citation:
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PMID: 15368569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caffeic acid and its derivatives are already known to possess a wide range of biological activities. We have developed quantitative structure-activity relationships (QSARs) for different series of caffeic acid derivatives (including caffeic acid) in order to understand the chemical-biological interactions governing antitumor activity against six different tumor cell lines, nitric oxide production, anti-HIV and enzymatic activities, and binding affinity to the lck domain. QSAR results have shown that the different activities of caffeic acid and its derivatives are largely dependent on their hydrophobicity or molar refractivity, with a bilinear correlation being the most important. |
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Authors:
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Rajeshwar P Verma; Corwin Hansch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chembiochem : a European journal of chemical biology Volume: 5 ISSN: 1439-4227 ISO Abbreviation: Chembiochem Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-15 Completed Date: 2005-03-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100937360 Medline TA: Chembiochem Country: Germany |
Other Details:
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Languages: eng Pagination: 1188-95 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Pomona College, Claremont, CA 91711, USA. rverma@pomona.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Anti-HIV Agents / chemistry, pharmacology Antineoplastic Agents, Phytogenic / chemistry, pharmacology Caffeic Acids / chemistry*, pharmacology* Cell Line, Tumor Chemistry, Physical Enzyme Inhibitors / chemistry, pharmacology Humans Ligands Lipoxygenase Inhibitors / chemistry, pharmacology Mice Nitric Oxide Synthase / antagonists & inhibitors Physicochemical Phenomena Quantitative Structure-Activity Relationship Receptors, Drug / chemistry src Homology Domains / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Antineoplastic Agents, Phytogenic; 0/Caffeic Acids; 0/Enzyme Inhibitors; 0/Ligands; 0/Lipoxygenase Inhibitors; 0/Receptors, Drug; EC 1.14.13.39/Nitric Oxide Synthase |
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