| Approach to elucidating the influences and factors affecting circulation system in humans in space environment. | |
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MedLine Citation:
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PMID: 21701089 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Many physiological changes associated with spaceflight, including decreases in orthostatic tolerance, exercise capacity, and blood volume have been reported. Orthostatic intolerance is a problem affecting many astronauts immediately postspaceflight. In particular, the relationship between orthostatic intolerance and cerebral autoregulation has been the focus of study in our research group. Although impairment of cerebral autoregulation was speculated to be one of the factors resulting in reduced post flight orthostatic tolerance, a 2-wk spaceflight study revealed that human cerebral autoregulation is preserved or even improved during and immediately after spaceflight in nonsymptomatic astronauts. To investigate the influences of the different kinds of reduction in central blood volume, we performed two ground-based studies. It is suggested that the mild intravascular dehydration partly explains the improved dynamic cerebral autoregulation observed during and immediately after a short-term spaceflight. Moreover, we also studied the relationship between orthostatic intolerance and cerebral autoregulation under hyperthermic conditions, because hyperthermia leads to orthostatic intolerance. Furthermore, we planned to conduct a study at the International Space Station (ISS) and ground-based studies to elucidate the influences and factors affecting the circulation system in humans in a space environment. |
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Authors:
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Ken Aoki; Yojiro Ogawa; Ken-Ichi Iwasaki; Chiaki Mukai |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nippon eiseigaku zasshi. Japanese journal of hygiene Volume: 66 ISSN: 0021-5082 ISO Abbreviation: Nippon Eiseigaku Zasshi Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-06-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417457 Medline TA: Nippon Eiseigaku Zasshi Country: Japan |
Other Details:
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Languages: eng Pagination: 568-72 Citation Subset: IM |
Affiliation:
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Division of Hygiene, Department of Social Medicine, Nihon University School of Medicine. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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