Document Detail


Approach to the complications of treatment for acute leukemia in the elderly.
MedLine Citation:
PMID:  16616047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute leukemia is common in the elderly and, due to the aging population and poorer prognosis, represents a major challenge. Elderly acute leukemia patients have been arbitrarily defined as >or=55 to 65 years of age and are underrepresented in clinical trials. There are physiologic differences between elderly and non-elderly patients. A comprehensive understanding of these differences allows the development of a systematic approach to assessing the risks for treatment-related complications. Use of a comprehensive geriatric assessment (CGA), initially developed and validated in the general geriatric population, may allow more accurate assessment of the likelihood of chemotherapy-induced complications and allow for proactive risk minimization. Once complications to therapy develop, aggressive treatment is essential. Treatment related to common complications that arise from therapy will be reviewed. Further research directed at this population is required.
Authors:
Joel Gingerich; Eric J Bow
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in hematology     Volume:  43     ISSN:  0037-1963     ISO Abbreviation:  Semin. Hematol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404514     Medline TA:  Semin Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-43     Citation Subset:  IM    
Affiliation:
Section of Haematology/Oncology, Department of Internal Medicine, the University of Manitoba, and the Department of Medical Oncology and Haematology, Cancer Care Manitoba, Winnipeg, Manitoba, Canada.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Antineoplastic Agents / adverse effects*
Geriatric Assessment
Humans
Leukemia / complications*,  drug therapy
Chemical
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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