| Approach to the complications of treatment for acute leukemia in the elderly. | |
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MedLine Citation:
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PMID: 16616047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute leukemia is common in the elderly and, due to the aging population and poorer prognosis, represents a major challenge. Elderly acute leukemia patients have been arbitrarily defined as >or=55 to 65 years of age and are underrepresented in clinical trials. There are physiologic differences between elderly and non-elderly patients. A comprehensive understanding of these differences allows the development of a systematic approach to assessing the risks for treatment-related complications. Use of a comprehensive geriatric assessment (CGA), initially developed and validated in the general geriatric population, may allow more accurate assessment of the likelihood of chemotherapy-induced complications and allow for proactive risk minimization. Once complications to therapy develop, aggressive treatment is essential. Treatment related to common complications that arise from therapy will be reviewed. Further research directed at this population is required. |
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Authors:
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Joel Gingerich; Eric J Bow |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in hematology Volume: 43 ISSN: 0037-1963 ISO Abbreviation: Semin. Hematol. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-17 Completed Date: 2006-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404514 Medline TA: Semin Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 134-43 Citation Subset: IM |
Affiliation:
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Section of Haematology/Oncology, Department of Internal Medicine, the University of Manitoba, and the Department of Medical Oncology and Haematology, Cancer Care Manitoba, Winnipeg, Manitoba, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Antineoplastic Agents / adverse effects* Geriatric Assessment Humans Leukemia / complications*, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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