| Approach to dysphagia in the young patient in the era of eosinophilic esophagitis. | |
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MedLine Citation:
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PMID: 20431968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eosinophilic esophagitis (EoE) has emerged as an important cause of dysphagia and food impactions in young adults. Previously considered a rare condition, an increasing number of cases of EoE have been attributable to a rising incidence and a growing awareness of the condition. Typical endoscopic features include concentric mucosal rings, linear furrowing, white exudates, and a narrow caliber esophagus. Current consensus guidelines define EoE by 1) the presence of characteristic symptoms, especially dysphagia and food impactions in adults, 2) >or= 15 eosinophils per high power field in esophageal tissue, and 3) exclusion of other disorders with similar presentations (eg, gastroesophageal reflux disease). Current knowledge about the pathophysiology implicates food allergens, aeroallergens, and genetic factors. The main treatment options for EoE are proton pump inhibitors, dietary manipulation, and topical or oral glucocorticoids. Endoscopic dilation may be performed in patients who do not respond to medical therapy. This review highlights recent insights into the diagnosis and management of EoE in young adults. |
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Authors:
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Nirmala Gonsalves |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current gastroenterology reports Volume: 12 ISSN: 1534-312X ISO Abbreviation: Curr Gastroenterol Rep Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888896 Medline TA: Curr Gastroenterol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 181-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, 676 St Clair St, Suite 1400, Chicago, IL, 60611-2951, USA. n-gonsalves@northwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Antibodies, Monoclonal / therapeutic use Clinical Protocols Deglutition Disorders* / drug therapy, etiology Diet Therapy Dilatation Eosinophilia* / complications, drug therapy Esophagitis* / complications, drug therapy Esophagoscopy Female Glucocorticoids / therapeutic use Humans Immunologic Factors / therapeutic use Male Proton Pump Inhibitors / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Glucocorticoids; 0/Immunologic Factors; 0/Proton Pump Inhibitors; 0/mepolizumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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