Document Detail


Approach to dysphagia in the young patient in the era of eosinophilic esophagitis.
MedLine Citation:
PMID:  20431968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eosinophilic esophagitis (EoE) has emerged as an important cause of dysphagia and food impactions in young adults. Previously considered a rare condition, an increasing number of cases of EoE have been attributable to a rising incidence and a growing awareness of the condition. Typical endoscopic features include concentric mucosal rings, linear furrowing, white exudates, and a narrow caliber esophagus. Current consensus guidelines define EoE by 1) the presence of characteristic symptoms, especially dysphagia and food impactions in adults, 2) >or= 15 eosinophils per high power field in esophageal tissue, and 3) exclusion of other disorders with similar presentations (eg, gastroesophageal reflux disease). Current knowledge about the pathophysiology implicates food allergens, aeroallergens, and genetic factors. The main treatment options for EoE are proton pump inhibitors, dietary manipulation, and topical or oral glucocorticoids. Endoscopic dilation may be performed in patients who do not respond to medical therapy. This review highlights recent insights into the diagnosis and management of EoE in young adults.
Authors:
Nirmala Gonsalves
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current gastroenterology reports     Volume:  12     ISSN:  1534-312X     ISO Abbreviation:  Curr Gastroenterol Rep     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888896     Medline TA:  Curr Gastroenterol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, 676 St Clair St, Suite 1400, Chicago, IL, 60611-2951, USA. n-gonsalves@northwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Antibodies, Monoclonal / therapeutic use
Clinical Protocols
Deglutition Disorders* / drug therapy,  etiology
Diet Therapy
Dilatation
Eosinophilia* / complications,  drug therapy
Esophagitis* / complications,  drug therapy
Esophagoscopy
Female
Glucocorticoids / therapeutic use
Humans
Immunologic Factors / therapeutic use
Male
Proton Pump Inhibitors / therapeutic use*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Glucocorticoids; 0/Immunologic Factors; 0/Proton Pump Inhibitors; 0/mepolizumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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