Document Detail

Appraisal of various thrombolytic agents in the treatment of acute myocardial infarction.
MedLine Citation:
PMID:  3115099     Owner:  NLM     Status:  MEDLINE    
The immediate therapeutic objective after the onset of symptoms of an evolving myocardial infarction is to stop the process from progressing. Evidence has accumulated that this can be accomplished by the early dissolution of the clot within an acutely thrombosed artery, resulting in reperfusion of the ischemic area. There are five clot-dissolving agents currently being evaluated by intravenous administration for their ability to dissolve coronary thrombi and to produce clinical benefit; all are plasminogen activators and each has distinctive properties. Streptokinase, because it has been the agent most extensively studied and its clinical benefits have been established, now serves as a standard for comparison with the others (anisoylated plasminogen-streptokinase activator complex, urokinase, recombinant tissue plasminogen activator, and recombinant pro-urokinase). It is apparent that each of the agents has advantages and disadvantages and that none has established its superiority over the others as of yet.
S Sherry
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of medicine     Volume:  83     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-10-06     Completed Date:  1987-10-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-46     Citation Subset:  AIM; IM    
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MeSH Terms
Coronary Circulation
Coronary Vessels
Fibrinolytic Agents / administration & dosage,  therapeutic use*
Hemorrhage / chemically induced
Hemostasis / drug effects
Heparin / adverse effects
Infusions, Intravenous
Myocardial Infarction / drug therapy*,  mortality
Plasminogen / therapeutic use
Streptokinase / administration & dosage,  adverse effects,  therapeutic use
Tissue Plasminogen Activator / adverse effects,  pharmacology,  therapeutic use
Urokinase-Type Plasminogen Activator / adverse effects,  therapeutic use
Reg. No./Substance:
0/Fibrinolytic Agents; 81669-57-0/Anistreplase; 9001-91-6/Plasminogen; 9005-49-6/Heparin; EC 3.4.-/Streptokinase; EC Plasminogen Activator; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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