Document Detail


Applying novel genome-wide linkage strategies to search for loci influencing type 2 diabetes and adult height in American Samoa.
MedLine Citation:
PMID:  18720898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Type 2 diabetes mellitus (T2DM) is a common complex phenotype that by the year 2010 is predicted to affect 221 million people globally. In the present study we performed a genome-wide linkage scan using the allele-sharing statistic Sall implemented in Allegro and a novel two-dimensional genome-wide strategy implemented in Merloc that searches for pairwise interaction between genetic markers located on different chromosomes linked to T2DM. In addition, we used a robust score statistic from the newly developed QTL-ALL software to search for linkage to variation in adult height. The strategies were applied to a study sample consisting of 238 sib-pairs affected with T2DM from American Samoa. We did not detect any genome-wide significant susceptibility loci for T2DM. However, our two-dimensional linkage investigation detected several loci pairs of interest, including 11q22 and 21q21, 9q21 and 11q22, 1p22-p21 and 4p15, and 4p15 and 15q11-q14, with a two-loci maximum LOD score (MLS) greater than 2.00. Most detected individual loci have previously been identified as susceptibility loci for diabetes-related traits. Our two-dimensional linkage results may facilitate the selection of potential candidate genes and molecular pathways for further diabetes studies because these results, besides providing candidate loci, also demonstrate that polygenic effects may play an important role in T2DM. Linkage was detected (p value of 0.005) for variation in adult height on chromosome 9q31, which was reported previously in other populations. Our finding suggests that the 9q31 region may be a strong quantitative trait locus for adult height, which is likely to be of importance across populations.
Authors:
Karolina Aberg; Guangyun Sun; Diane Smelser; Subba Rao Indugula; Hui-Ju Tsai; Matthew S Steele; John Tuitele; Ranjan Deka; Stephen T McGarvey; Daniel E Weeks
Related Documents :
12509788 - Cold-induced sweating syndrome is caused by mutations in the crlf1 gene.
18980218 - Familial dyskinesia and facial myokymia (fdfm): follow-up of a large family and linkage...
10845568 - Localization of an acromesomelic dysplasia on chromosome 9 by homozygosity mapping.
15616038 - Linkage of plasma adiponectin levels to 3q27 explained by association with variation in...
10093378 - Genetic polymorphism of cyp1a1 and cyp2d6 in the tundra nentsi population of siberia.
1497888 - Evidence for differential maturation of reciprocal sperm segregants in the murine rb(6....
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human biology     Volume:  80     ISSN:  0018-7143     ISO Abbreviation:  Hum. Biol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2008-10-22     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  0116717     Medline TA:  Hum Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-123     Citation Subset:  IM    
Affiliation:
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, A300 Crabtree Hall, 130 Desoto St., Pittsburgh, PA 15261, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
American Samoa / epidemiology
Anthropometry
Body Height / physiology*
Diabetes Mellitus, Type 2 / epidemiology,  genetics*
Disease Susceptibility
Female
Genetic Markers
Genome, Human*
Genotype
Humans
Male
Middle Aged
Phenotype
Grant Support
ID/Acronym/Agency:
AG09375/AG/NIA NIH HHS; DK55406/DK/NIDDK NIH HHS; DK59642/DK/NIDDK NIH HHS; HL52611/HL/NHLBI NIH HHS; R01 AG009375/AG/NIA NIH HHS; R01 DK059642/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Online video game therapy for mental health concerns: a review.
Next Document:  Temporal, seasonal, and regional differences in births and deaths in Aland (Finland).