| Applying heart failure guidelines to adult congenital heart disease patients. | |
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MedLine Citation:
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PMID: 18248271 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is a growing population of adult patients with congenital heart defects in the developed world. Most have been repaired, but few have been cured. Many have myocardial dysfunction. Most have exercise intolerance. Some have heart failure. As a group, they show neurohormonal activation similar to that seen in an adult heart failure population with acquired heart disease. Currently, the patients at greatest risk of heart failure are those without a systemic left ventricle, such as Mustard and Senning repairs of transposition of the great arteries (TGA), congenitally corrected TGA, and patients who have had a Fontan procedure. Exercise intolerance may predict hospitalization and death in such patients. For those patients with systemic left ventricles, it would seem reasonable to use the heart failure guidelines developed for patients with acquired heart disease. For those patients without a systemic left ventricle (e.g., a systemic right ventricle or single ventricle), there is currently no foundation for evidence-based therapy. |
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Authors:
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Robert E Shaddy; Gary Webb |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert review of cardiovascular therapy Volume: 6 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-05 Completed Date: 2008-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 165-74 Citation Subset: IM |
Affiliation:
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Division of Cardiology, The Children's Hospital of Philadelphia, and University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104-4399, USA. shaddyr@email.chop.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / metabolism Cardiovascular System / physiopathology Heart Defects, Congenital / complications, physiopathology, therapy* Heart Failure / etiology, therapy* Heart Ventricles / abnormalities Humans Neurotransmitter Agents / metabolism Practice Guidelines as Topic* Ventricular Function |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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