| Applying decision analysis to management of adolescent idiopathic nephrotic syndrome. | |
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MedLine Citation:
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PMID: 7696099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Due to the concern that adolescents presenting with nephrotic syndrome are less likely to have minimal change disease than younger children, pediatric nephrologists have tended toward renal biopsy-tailored treatment rather than corticosteroid use in this population. The need for biopsy prior to treatment of nephrotic syndrome in adults has been challenged. A similar challenge to the clinical need for this procedure in adolescents with idiopathic nephrotic syndrome is raised here. The principles of medical decision analysis were applied and calculations were made with the Decision Maker computer program. The life expectancy of an adolescent who receives biopsy-tailored treatment was found to be no different from that of an adolescent who receives empiric corticosteroid treatment. We conclude that renal biopsy is not mandatory for the clinical management of adolescents with idiopathic nephrotic syndrome. Prognostically, a response, or lack thereof, to empiric corticosteroid therapy may be just as informative as a histological diagnosis. |
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Authors:
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M M Moxey-Mims; F B Stapleton; L G Feld |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 8 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-05-02 Completed Date: 1995-05-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 660-4 Citation Subset: IM |
Affiliation:
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Children's Kidney Center, Children's Hospital of Buffalo, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenal Cortex Hormones / therapeutic use* Biopsy* Data Interpretation, Statistical Decision Support Techniques* Humans Male Nephrotic Syndrome / drug therapy*, pathology Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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