Document Detail

Applied Healthspan engineering.
MedLine Citation:
PMID:  20462384     Owner:  NLM     Status:  MEDLINE    
According to the Homeric Hymn to Aphrodite, when Eos asked Zeus for Tithonus to be granted immortality, she forgot to ask for eternal youth. Applied Healthspan Engineering (AHE) seeks to address this problem. All organisms have a minimal level of functional reserve required to sustain life that eventually declines to a point incompatible with survival at death. AHE seeks to maintain or restore optimal functional reserve of critical tissues and organs. Tissue reserve correlates with well being. Diet, physical exercise, and currently available small-molecule-based therapeutics may attenuate the rate of decline of specific organs or organ systems, but are unlikely to restore lost reserve. Inherent evolutionary-derived limitations in tissue homeostasis and cell maintenance necessitate the development of therapies to enhance regenerative processes and possibly replace whole organs or tissues. AHE supports the study of cell, tissue, and organ homeostatic mechanisms to derive new regenerative and tissue replacement therapies to extend the period of human health.
James W Larrick; Andrew Mendelsohn
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Rejuvenation research     Volume:  13     ISSN:  1557-8577     ISO Abbreviation:  Rejuvenation Res     Publication Date:    2010 Apr-Jun
Date Detail:
Created Date:  2010-05-13     Completed Date:  2010-08-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101213381     Medline TA:  Rejuvenation Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-80     Citation Subset:  IM    
Panorama Research Institute and Regenerative Sciences Institute, Sunnyvale, California 94089, USA.
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MeSH Terms
Age Factors
Aging / metabolism,  pathology,  physiology*
Animal Structures / metabolism,  physiology
Bioengineering / methods*,  trends
Energy Metabolism / physiology
Health Status
Longevity / genetics,  physiology*
Models, Biological
Quality of Life
Regeneration / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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