Document Detail

Applications of particle microbeams in space radiation research.
MedLine Citation:
PMID:  19346685     Owner:  NLM     Status:  MEDLINE    
Galactic cosmic radiation is acknowledged as one of the major barriers to human space exploration. In space, astronauts are exposed to charged particles from Z = 1 (H) up to Z = 28 (Ni), but the probability of a hit to a specific single cell in the human body is low. Particle microbeams can deliver single charged particles of different charge and energy to single cells from different tissues, and microbeam studies are therefore very useful for improving current risk estimates for long-term space travel. 2D in vitro cell cultures can be very useful for establishing basic molecular mechanisms, but they are not sufficient to extrapolate risk, given the substantial evidence proving tissue effects are key in determining the response to radiation insult. 3D tissue or animal systems represent a more promising target for space radiobiology using microbeams.
Marco Durante
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of radiation research     Volume:  50 Suppl A     ISSN:  0449-3060     ISO Abbreviation:  J. Radiat. Res.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-06-10     Revised Date:  2012-03-28    
Medline Journal Info:
Nlm Unique ID:  0376611     Medline TA:  J Radiat Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  A55-8     Citation Subset:  IM    
GSI, Biophysics Department, and Technical University of Darmstadt, Planckstrasse 1, D-64291 Darmstadt, Germany.
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MeSH Terms
Biological Assay / instrumentation*,  methods
Cell Culture Techniques / instrumentation*,  methods
Cell Physiological Phenomena / radiation effects*
Dose-Response Relationship, Radiation*
Equipment Design
Radiation Dosage
Radiobiology / instrumentation*,  methods
Space Flight / instrumentation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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