| Applications of modulated differential scanning calorimetry in preformulation studies. | |
MedLine Citation:
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PMID: 10703989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Characterization of the thermal properties of active pharmaceutical ingredients is critical in the selection of appropriate physical forms for development and defining proper manufacturing, handling and storage conditions of those chemical entities. Modulated differential scanning calorimetry (MDSC) has proven to be an effective tool in the thorough characterization of thermal behavior of compounds in preformulation studies. Selected applications of MDSC for various preclinical compounds are presented, thereby demonstrating the utility of this analytical method in the determination of glass transitions, characterization of desolvation and degradation processes as well as in the study of polymorphic transformations and crystallizations. |
Authors:
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S R Rabel; J A Jona; M B Maurin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: 21 ISSN: 0731-7085 ISO Abbreviation: J Pharm Biomed Anal Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-03-13 Completed Date: 2000-03-13 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 339-45 Citation Subset: IM |
Affiliation:
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Pharmacy R&D, DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880-0400, USA. shelley.r.rabel@dupontpharma.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calorimetry, Differential Scanning
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methods* Chemistry, Pharmaceutical* Excipients / chemistry Losartan / chemistry Pharmaceutical Preparations / chemistry Temperature Thermodynamics Water |
| Chemical | |
Reg. No./Substance:
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0/Excipients; 0/Pharmaceutical Preparations; 114798-26-4/Losartan; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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