Document Detail

Applications of modulated differential scanning calorimetry in preformulation studies.
MedLine Citation:
PMID:  10703989     Owner:  NLM     Status:  MEDLINE    
Characterization of the thermal properties of active pharmaceutical ingredients is critical in the selection of appropriate physical forms for development and defining proper manufacturing, handling and storage conditions of those chemical entities. Modulated differential scanning calorimetry (MDSC) has proven to be an effective tool in the thorough characterization of thermal behavior of compounds in preformulation studies. Selected applications of MDSC for various preclinical compounds are presented, thereby demonstrating the utility of this analytical method in the determination of glass transitions, characterization of desolvation and degradation processes as well as in the study of polymorphic transformations and crystallizations.
S R Rabel; J A Jona; M B Maurin
Related Documents :
18987579 - Study of pro- and anti-oxidative properties of d-penicillamine in a system comprising h...
22796869 - In depth study of acrylamide formation in coffee during roasting: role of sucrose decom...
10521709 - Manipulation of cholesterol and cholesteryl ester synthesis has multiple effects on the...
19957079 - Pyrazines: occurrence, formation and biodegradation.
756949 - Microbial degradation of diethanolamine and related compounds.
19601579 - Oxidation of the dihydrochalcone aspalathin leads to dimerization.
24195699 - Determination of magnitudes and relative signs of 1h-19f coupling constants through 1d-...
24246729 - Synthesis and evaluation of new coumarin-pyridine hybrids with promising anti-osteoporo...
23591539 - New advances in dual stereocontrol for asymmetric reactions.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  21     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-03-13     Completed Date:  2000-03-13     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  339-45     Citation Subset:  IM    
Pharmacy R&D, DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880-0400, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Calorimetry, Differential Scanning / methods*
Chemistry, Pharmaceutical*
Excipients / chemistry
Losartan / chemistry
Pharmaceutical Preparations / chemistry
Reg. No./Substance:
0/Excipients; 0/Pharmaceutical Preparations; 114798-26-4/Losartan; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Determination of barbiturates in urine by micellar liquid chromatography and direct injection of sam...
Next Document:  Microbiological bioassay of erythromycin thiocyanate: optimisation and validation.