Document Detail


Applications of modulated differential scanning calorimetry in preformulation studies.
MedLine Citation:
PMID:  10703989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Characterization of the thermal properties of active pharmaceutical ingredients is critical in the selection of appropriate physical forms for development and defining proper manufacturing, handling and storage conditions of those chemical entities. Modulated differential scanning calorimetry (MDSC) has proven to be an effective tool in the thorough characterization of thermal behavior of compounds in preformulation studies. Selected applications of MDSC for various preclinical compounds are presented, thereby demonstrating the utility of this analytical method in the determination of glass transitions, characterization of desolvation and degradation processes as well as in the study of polymorphic transformations and crystallizations.
Authors:
S R Rabel; J A Jona; M B Maurin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  21     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-03-13     Completed Date:  2000-03-13     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  339-45     Citation Subset:  IM    
Affiliation:
Pharmacy R&D, DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880-0400, USA. shelley.r.rabel@dupontpharma.com
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MeSH Terms
Descriptor/Qualifier:
Calorimetry, Differential Scanning / methods*
Chemistry, Pharmaceutical*
Excipients / chemistry
Losartan / chemistry
Pharmaceutical Preparations / chemistry
Temperature
Thermodynamics
Water
Chemical
Reg. No./Substance:
0/Excipients; 0/Pharmaceutical Preparations; 114798-26-4/Losartan; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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